| 秋茄枝乙醇提取物减轻链脲佐菌素诱导的大鼠肝脏和胰腺病理损伤 |
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| 引用本文： | 黄绵庆杨照新王小蒙王世雄符健.秋茄枝乙醇提取物减轻链脲佐菌素诱导的大鼠肝脏和胰腺病理损伤[J].现代生物医学进展,2012,12(11):2061-2064. |
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| 作者姓名： | 黄绵庆杨照新王小蒙王世雄符健 |
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| 作者单位： | 海南医学院 海南海口571101 |
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| 基金项目： | 海南省自然科学基金项目(309031) |
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| 摘 要： | 目的:研究秋茄枝乙醇提取物(EEK)对链脲佐菌素(STZ)诱导的2型糖尿病(T2DM)大鼠肝脏和胰腺组织病理结构的影响。方法:以高脂饲料喂养联合STZ建立T2DM大鼠模型。大鼠分为为正常对照组、T2DM模型组、二甲双胍组、EEK低、中、高剂量组。大鼠给药4周后处死,取肝脏和胰腺进行组织病理学检查。结果:随着EEK剂量的增加,大鼠肝脏和胰岛组织的病理损伤逐步减轻。结论:EEK有助于修复STZ诱导的T2DM大鼠受损的肝脏和胰岛组织。
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| 关 键 词： | 秋茄 2型糖尿病 链脲佐菌素 |
Ethanol Extract from Kandelia Candel Trunk Reduces Pathological Damages
of Liver and Pancreas in Rats Induced by Streptozotocin |
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| HUANG Mian-qing,YANG Zhao-xin,WANG Xiao-meng,WANG Shi-xiong,FU Jian.Ethanol Extract from Kandelia Candel Trunk Reduces Pathological Damages
of Liver and Pancreas in Rats Induced by Streptozotocin[J].Progress in Modern Biomedicine,2012,12(11):2061-2064. |
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| Authors: | HUANG Mian-qing YANG Zhao-xin WANG Xiao-meng WANG Shi-xiong FU Jian |
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| Institution: | (Hainan Medical College,Haikou 571101,China) |
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| Abstract: | Objective: To investigate the effect of ethanol extract from kandelia candel trunk(EEK) on pathological structure of liver and pancreas in type 2 diabetes mellitus(T2DM) rats induced by streptozotocin.Methods: The T2DM rat model was induced with high-fat diet and STZ.Rats were devided into normal control group,model group,metformin group,EEK low-dose group,EEK medium-dose group and EEK high-dose group.After 4W administration,the rats were sacrificed to perform histopathological examination.Results: The pathological damages of liver and pancreas were gradually reduced with increasing dosages of EEK in Rats Conclusion: EEK contributes to repairing damaged liver and pancreas in T2DM rats induced by STZ. |
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| Keywords: | Kandelia candel Type 2 diabetes mellitus Streptozotocin |
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