系统性红斑狼疮患者血清中IL-17 的检测及临床意义

目的:通过检测系统性红斑狼疮(SLE)患者外周血中IL-17的水平,探讨其临床意义。方法:用酶联免疫吸附法(enzymelinked immunosorbent assay,ELISA)检测61例SLE患者及30例健康人血清IL-17水平,并收集整理SLE患者的临床资料及实验室数据,分析其与临床的关系。结果:活动期SLE患者血清IL-17水平明显高于正常对照组(P<0.01),与SLE非活动组相比,差异亦有统计学意义(P<0.01)。但SLE非活动组与正常对照组间无统计学意义。结论:IL-17水平在活动期SLE患者血清中表达明显增高,且与SLEDAI评分呈正相关,提示IL-17可能参与了SLE疾病的病理过程,可能与疾病活动的关系密切。

The Detection and Clinical Significance of Serum IL-17 in Patients with Systemic Lupus Erythematosus

Objective:To analyze the levels of interleukin 17(IL-17)in the peripheral blood of patients with SLE,and to investigate the clinical significance.Methods: IL-17 levels were assessed in 61 SLE patients and 30 normal controls by enzyme-linked immunosorbent assay(ELISA).And the clinical and laboratory data of the patients were collected.To explor the relationship between IL-17 and clinical of SLE patients.Results: The plasma concentration of IL-17 was significantly elevated in SLE patients as compaired to the normal control group(P<0.01).Compared with patients wi th inactive SLE,the levels of IL-17 had the statistic differences,and there showed no statistic differences between patients with inactive SLE and normal controls.Conclusion: IL-17 in the sera of untreated SLE patients is significantly higher,and the levels of them are positively correlated with SLEDAI scores.The results suggest that IL-17 may play an important role in the pathogenesis of SLE,especially in active SLE.