|
|||||
|
|
| 硫柳汞SD 大鼠单次静脉注射药代动力学研究 | |
| 引用本文： | 栗克喜,雷宁,沈富兵,朱逸,郑崛村.硫柳汞SD 大鼠单次静脉注射药代动力学研究[J].现代生物医学进展,2012,12(3):426-429. |
| 作者姓名： | 栗克喜 雷宁 沈富兵 朱逸 郑崛村 |
| 作者单位： | 1. 中国医药集团总公司成都生物制品研究所 四川成都610023 2. 成都理工大学材料与化学化工学院化工与制药系 四川成都610059 3. 成都医学院检验医学院 四川成都610083 |
| 基金项目： | 国家科技支撑计划课题(2008BAI54B05) |
| 摘 要： | 目的:研究硫柳汞在SD大鼠静脉注射后的药代动力学特征。方法:SD大鼠单剂量(高、低2个剂量组)静脉注射硫柳汞,以冷原子吸收测汞法测定不同时间点的血药浓度,用DAS2.0软件获取各剂量组的主要药代动力学参数。结果:硫柳汞在高(30mg/kg)和低剂量(15 mg/kg)的消除半衰期t1/2z分别为171.61±0.33h,,156.54±18.61h;AUC0-144h分别为16748.65±7296.61mg/L*h,9131.94±1406.68 mg/L*h。结论:硫柳汞在大鼠体内的代谢过程呈线性动力学特征,半衰期约在130～170h左右。 |
| 关 键 词： | 硫柳汞 毒代动力学 冷原子吸收法 |
Pharmacokinetics of Thiomersal in SD Rats Following Intraveous Administration |
|
| LI Ke-xi,LEI Ning,SHEN Fu-bing,ZHU Yi,ZHENG Jue-cun.Pharmacokinetics of Thiomersal in SD Rats Following Intraveous Administration[J].Progress in Modern Biomedicine,2012,12(3):426-429. | |
| Authors: | LI Ke-xi LEI Ning SHEN Fu-bing ZHU Yi ZHENG Jue-cun |
| Institution: | 1 Chengdu Institute of Biological Products,Chengdu 610023,China; 2 Department of Chemical & Pharmaceutical Engineering,College of Materials and Chemistry & Chemical Engineering,Chengdu University of Technology,Chengdu 610059,China; 3 Department of Medical Laboratory,Chengdu Medical College,Chengdu 610083,China) |
| Abstract: | Objective: To study the pharmacokinetics of Thiomersal in rats after intravenous injection.Methods: Thiomersal was intravenously injected to SD rats,once at 15mg/kg and 30mg/kg respectively.Blood samples were serially collected and the mercury level was determinated by cold-vapour atomic absorption spectroscopy.Pharmacokinetic parameters were integrated using DAS 2.0 software.Results: At the dose of 30 mg/kg and 15 mg/kg,the half-life of Thiomersal were 171.61±0.33h and 156.54±18.61h respectively,and AUC0-144h were 16748.65±7296.61 mg/L*h and 9131.94±1406.68 mg/L*h,respectively.Conclusion: Thiomersal presented a linear Pharmacokinetics in the metabolism process of rats with half-life of about 130 ~ 170h or so. |
| Keywords: | Thiomersal Pharmacokinetics Cold atomic absorption |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《现代生物医学进展》浏览原始摘要信息 | |
| 点击此处可从《现代生物医学进展》下载免费的PDF全文 | |