脐带间充质干细胞移植治疗脊髓损伤的临床研究

目的:探讨脐带间充质干细胞移植治疗脊髓损伤的疗效及安全性。方法:40例脊髓损伤患者给予脐带间充质干细胞移植治疗,移植方法采用静脉输注联合腰穿鞘内注射的方法。术后随访1年余定期观察患者临床症状及各项指标的变化并进行综合分析。移植过程中为促进干细胞的生长和分化,根据患者病情及身体状况给予相应的康复功能锻炼。结果:与入院时比较,脐带间充质干细胞移植治疗3、6、12个月后,不完全性脊髓损伤患者针刺觉评分、轻触觉评分、运动评分均有明显改善(P<0.05或0.01),完全性脊髓损伤患者针刺觉评分、轻触觉评分、运动评分均无明显变化(P>0.05),两组残损分级均无明显改善(P>0.05)。移植后各项生化指标正常,未出现严重的并发症和明显的不良反应。结论:脐带间充质干细胞移植治疗脊髓损伤近期疗效明显,可以改善患者的临床症状,提高患者的生存质量,是一种值得借鉴的治疗方法。

Clinical Study of Umbilical Cord Mesenchymal Stem Cell Transplantation Therapy for Spinal Cord Injury

Objective: To observe the clinical effect and safety of umbilical cord mesenchymal stem cells(UC-MSC) transplantation therapy for spinal cord injury.Methods: Forty patients with spinal cord injury were received UC-MSC transplantation by intravenous infusion and lumbar puncture intrathecal injections.All patients were followed up for more than one year after transplantation.Clinical symptoms and various index were observed and literature review was performed.All patients were received corresponding recovery function exercise according to the disease condition for promoting the stem cell growth and differentiation.Results: At the 1,3,and 12 months after UC-MSC transplantation,the pin prick score,light touch score,and motor score of the patients in the incomplete spinal cord iniury group had the obvious improvement compared with those on admission(P<0.05 or 0.01),while the pin prick score,light touch score and motor score of the patients in the complete spinal cord injury group had no obvious change.There was no obvious improvement in impairment classification in the two group(P>0.05).Various biochemical indicators were normal and the patients had no severe complications and clear side effects after transplantation.Conclusions: The UCB-MSC transplantation can ameliorate clinical manifestations and improve quality of life of spinal cord injury.It is convenient,safe and effective in the treatment of spinal cord injury.