肝旺痰阻型高血压大鼠模型的建立和评价研究

目的:建立和评价肝旺痰阻型高血压大鼠模型。方法:采用自发性高血压大鼠,以长期激怒联合高质饮食法建立肝旺痰阻的复合证候。通过观察大鼠性情动态的变化及体重、血压及血脂和血管紧张素Ⅱ的变化,对高血压大鼠肝旺痰阻证型进行综合评价。结果:模型组大鼠在性情动态及体重、血压、血脂和血管紧张素Ⅱ等方面均与对照组有较大差异(P<0.05),符合了中医肝旺痰阻证型的表现。结论:采用自发性高血压大鼠,以长期激怒联合高质饮食法,可建立肝旺痰阻型高血压大鼠动物模型。

Establishment and Evaluation of a Rat Model of Hypertension with Liver Prosperity and Phlegm Obstruction Syndrome

Objective: To establish and evaluate the model of spontaneity hypertension rat with liver prosperity and phlegm ob-struction syndrome.Methods: To choose spontaneity hypertension rat and adopt the method of slow irritation and fat-rich diet to establish complex syndrome of liver prosperity and phlegm obstruction,by observing the dynamic changes of the temperament and weight,blood pressure,blood fat and angiotensinⅡ,comprehensively evaluated the rats with liver prosperity and phlegm obstruction syndrome.Results: Dynamic changes of the temperament and weight,blood pressure,blood fat and angiotensinⅡ in the model group had a significant differ-ence compared with controls(p<0.05),conformed to the characteristic of liver prosperity and phlegm obstruction syndrome.Conclusions: The model of spontaneity hypertension rat with liver prosperity and phlegm obstruction syndrome could be established by means of slow irritation and fat-rich diet.