胶质细胞源性神经营养因子对疼痛的调节作用

胶质细胞源性神经营养因子(glial cell derived neurotrophic factor,GDNF)属转化生长因子β超家族成员,其成熟蛋白由134个氨基酸残基组成,而GDNF受体广泛分布于外周和中枢神经系统。GDNF不仅可以促进多巴胺能神经元、运动神经元的存活,对交感、副交感以及感觉神经元具有营养作用,还能够影响神经元的发育、分化并对非神经系统的发育也具有重要作用。近年来随着人们对疼痛认识的深入,疼痛的机制也不再限于神经元功能的改变,还受胶质细胞活化、多种营养因子、细胞因子及相应受体、离子通道等多方面因素的影响。为此,本文就近年来GDNF参与疼痛调节的相关研究进展做一简要综述。

Regulatory Effect of Glial Cell Derived Neurotrophic Factor on Pain

Glial cell derived neurotrophic factor-GDNF belongs to the transforming growth factor-β (TGF-β ) superfamily.The mature GDNF protein comprises 134 amino acid residues,and GDNF receptors are widely distributed in peripheral and central nervous system.GDNF is not only a survival factor for dopaminergic neurons and motoneurons,but plays an important role in the trophism of sympathetic neurons,parasympathetic neurons and sensory neurons,as well as the development and differentiation of neurons and unnervous system.In these years,with the deepening cognition of pain,the mechanism of pain has not been limited only in the change of functions of neurons,but refers to the activation of glial cells,many trophic factors,cytokines and their corresponding acceptors,ion channels and so on.This article reviews the regulatory effect of GDNF family on inflamatory pain and neuropathic pain according to a variety of evidences on these issues in recent years.