| 苄丝肼微球的体外释放行为 |
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| 引用本文： | 蔡云鹏马柳青张文君王兆敏张袁魁朱云婷袁伟恩.苄丝肼微球的体外释放行为[J].现代生物医学进展,2012,12(11):2158-2159. |
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| 作者姓名： | 蔡云鹏马柳青张文君王兆敏张袁魁朱云婷袁伟恩 |
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| 作者单位： | 上海交通大学 上海 200240 |
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| 基金项目： | 国家重大专项-“重大新药创制”制剂平台(2009ZX09310-007);国家自然科学基金(81171203);上海科委纳米专项(1052nm03900);上海交通大学大学生创新项目(IPP2090) |
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| 摘 要： | 采用S/O/W和W/O/W法,和不同的苄丝肼载药量制作缓释微球,用HPLC考察其释放曲线、突释情况和包封率,实验表明S/O/W法制作的苄丝肼微球缓释效果更好,达到了6d,包封率能达到70%以上,突释情况可以接受,苄丝肼载药量低的微球能达到更高的包封率。
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| 关 键 词： | 苄丝肼 微球 缓释 包封率 |
Release of Benserazide-loaded Microspheres in Vitro |
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| CAI Yun-peng,MA Liu-qing,ZHANG Wen-jun,WANG Zhao-min,ZHANG Yuan-kui,ZHU Yun-ting,YUAN Wei-en.Release of Benserazide-loaded Microspheres in Vitro[J].Progress in Modern Biomedicine,2012,12(11):2158-2159. |
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| Authors: | CAI Yun-peng MA Liu-qing ZHANG Wen-jun WANG Zhao-min ZHANG Yuan-kui ZHU Yun-ting YUAN Wei-en |
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| Institution: | (Shanghai Jiao Tong University,Shanghai 200240,China) |
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| Abstract: | To prepare benserazide-loaded sustained release microsphere using W/O/W and S/O/W method,and with different amount of drug loading.The release was detected by HPLC,and analyzed the drug release,initial burst and the encapsulation efficiency.The results suggest that the microspheres made by S/O/W method work better in sustained release,which reaches 6 days,the encapsula-tion efficiency can be more than 70%,the initial burst is acceptable,and the lower the drug loading is,the higher the encapsulation effi-ciency can be. |
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| Keywords: | Benserazide Microspheres Sustained release Encapsulation efficiency |
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