尼莫地平治疗高血压性脑出血疗效观察

目的:尼莫地平治疗高血压性脑出血的临床疗效。方法:90例高血压脑出血患者随机分为实验组(45例)和对照组(45例),对照组仅采用常规治疗,实验组在常规治疗的基础上采用尼莫地平进行治疗,比较两组临床疗效、治疗前后的临床神经功能缺损评分、临床残疾评分以及血肿和水肿带体积改变。结果:实验组和对照组的治疗有效率为73.33%和42.22%,差异具有统计学意义(P<0.05)。实验组和对照组治疗前、后临床神经功能缺损评分分别为(18.58±3.06)、(12.31±2.74)和(18.28±2.97)、(15.22±2.72),实验组和对照组治疗前、后临床残疾评分分别为(38.93±3.37)、(61.57±3.03)和(37.51±4.962)和(43.48±7.19),实验组和对照组治疗前、后的血肿体积分别为(17.23±5.48)cm3、(7.93±3.33)cm3和(17.60±5.46)cm3、(10.97±4.25)cm3,实验组和对照组治疗前、后的水肿带体积分别为(7.73±3.20)cm3、(4.21±1.60)cm3和(7.83±3.19)cm3和(5.67±1.82)cm3,所有患者治疗后各指标均优于治疗前,治疗后两组组间比较均有有显著性(P<0.01)。结论:尼莫地平能够明显的减少血肿体积和水肿带的体积,提高治疗的效果,减少脑出血患者发生神经功能缺损和残疾的可能。

Clinical Effects of Nimodipine in Treatment of Hypertensive Intracerebral Hemorrhage

Objective:To study the clinical effective of nimodipine in treatment of hypertensive intracerebral hemorrhage patients.Methods: Ninety patients with hypertensive Intranetcerebral hemorrhage were randomly divided into experimental group(45 cases) and control group(45 cases),and the patients in control group were treated with conventional therapy,and those in the experimental group were treated with nimodipine basis of conventional therapy.The clinical efficacy,the clinical neurological deficit score,clinical disability score,hematoma and edema volume change were observed before and after treatment and compared between the two groups.Results: The effective rates were 73.33% in the experimental group and 42.22% in the control group with statistically significant(P<0.05).The clinical neurological deficit scores of the patients in experimental group were(18.58 ±3.06) before treatment and(12.31 ±2.74) after treatment,which were(18.28 ±2.97) before and(15.22 ±2.72) after treatment in the control group;The clinical disability scores of experimental group before and after treatment were(38.93 ±3.37) and(61.57 ±3.03),and were(37.51 ±4.962) and(43.48 ±7.19) in the control group before and after treatment;the hematoma volume of experimental group before and after treatment were(17.23 ±5.48) cm3 and(7.93 ±3.33) cm3,which were(17.60 ±5.46) cm3and(10.97 ±4.25) cm3for the control group before and after treatment;The edema volume experimental group before and after treatment were(7.73 ±3.20) cm3and(4.21 ±1.60) cm3,which were(7.83 ±3.19) cm3 and(5.67 ±1.82) cm3in the control group before and after treatment.Compared with these indexes before treatment,all of these indexes were improved after treatment(P<0.01),moreover,these indexes were better in experiment group than those in control group after treatment(P<0.01).Conclusions: Nimodipine can significantly reduce the hematoma volume and the volume of edema and improve the therapeutic effect and reduce the rate of neurologic impairment and disability occurrence on the intracerebral hemorrhage patients.