|
|||||
|
|
| 姜黄素抑制大鼠C6 胶质瘤生成及机制初步研究 | |
| 引用本文： | 田刚,雷宁,王晓娟,樊明新,陈祖容,韩瑞军,曾庆乐,夏永勤,李华.姜黄素抑制大鼠C6 胶质瘤生成及机制初步研究[J].现代生物医学进展,2012,12(4):635-637. |
| 作者姓名： | 田刚 雷宁 王晓娟 樊明新 陈祖容 韩瑞军 曾庆乐 夏永勤 李华 |
| 作者单位： | 1. 兰州军区乌鲁木齐总医院神经外科 新疆乌鲁木齐830000 2. 成都理工大学材料与化学化工学院化工与制药系 四川成都610059 3. 解放军第23医院临床部药械科 新疆乌鲁木齐830000 4. 福建省莆田市涵江区涵江医院神经外科 福建莆田351111 |
| 基金项目： | 广东省食品药品职业学院院级课题（2009YZ001） |
| 摘 要： | 目的:观察姜黄素对大鼠C6胶质瘤的抑制作用。方法:将SD大鼠随机分为假手术组、模型组、姜黄素高、低剂量组。各组动物于移植术后7天给予干预,姜黄素组给予姜黄素灌胃,14天后处死。分离肿瘤测量其体积,realtime RT-PCR法和western blot法检测肿瘤组织中核转录因子-κ B(nuclear factor-κ B,NF-κB)、EGFR mRNA和蛋白的表达。结果:姜黄素能明显降低肿瘤体积,降低肿瘤组织中NF-κ B、EGFR mRNA和蛋白的表达。结论:姜黄素能抑制大鼠C6胶质瘤的生长,其机制可能与抑制NF-κ B、EGFR表达有关。 |
| 关 键 词： | 姜黄素 胶质瘤 NF-κ B EGFR |
The Inhibitive effect of Curcumine on Implanted C6 Neurogliocytoma in Rats |
|
| TIAN Gang,LEI Ning,WANG Xiao-juan,FAN Ming-xin,CHEN Zu-rong,HAN Rui-jun,ZENG Qing-le,XIA Yong-qin,LI Hua.The Inhibitive effect of Curcumine on Implanted C6 Neurogliocytoma in Rats[J].Progress in Modern Biomedicine,2012,12(4):635-637. | |
| Authors: | TIAN Gang LEI Ning WANG Xiao-juan FAN Ming-xin CHEN Zu-rong HAN Rui-jun ZENG Qing-le XIA Yong-qin LI Hua |
| Institution: | 1(1.Department of neurosurgery of Urumqi General Hospital in Lanzhou Military Area Command,Urumqi 830000 2.Department of Chemical & Pharmaceutical Engineering,College of Material and Chemistry & Chemical Engineering,Chengdu University of Technology.Chengdu 610059 3.Department of Clinical Drug and Equipment Section,The 23th hospital of Chinese People’s Liberation Army,Urumqi 830000 4.Department of Neurosurgery,The Hanjiang Hospital of Putian City,Putian,351111) |
| Abstract: | Objective: To study the effect of curcumine on implanted neurogliocytoma in rats.Methods: Sprague Dawley rats were divided into normal group,sham operated group and three curcumine groups.Contents of NF-κB and EGFR protein and mRNA were detected by immunohistochemical and real-time PCR methods,respectivly.Results: In curcumine groups,Contents of NF-κB and EGFR protein and mRNA were decreased markedly.Conclusion: Curcumine could inhibit the implanted neurogliocytoma in rats.This maybe be concerned with that it could inhibit the expression of NF-κB and EGFR in the implanted neurogliocytoma in rats. |
| Keywords: | Curcumine Neurogliocytoma NF-κ B EGFR |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《现代生物医学进展》浏览原始摘要信息 | |
| 点击此处可从《现代生物医学进展》下载免费的PDF全文 | |