| EB 病毒LMP1 在肿瘤研究中的进展 |
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| 引用本文： | 唐微朱建思.EB 病毒LMP1 在肿瘤研究中的进展[J].现代生物医学进展,2012,12(7):1394-1397. |
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| 作者姓名： | 唐微朱建思 |
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| 作者单位： | 南华大学医学院肿瘤研究所 湖南衡阳421001 |
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| 摘 要： | EB病毒(Epstein-Barr virus,EBV)是具有致瘤潜能的疱疹病毒,与多种恶性肿瘤的发生相关。EB病毒编码的潜伏性膜蛋白1(Latent membrane protein-1,LMP1)作为其主要的致瘤蛋白,能通过细胞内多种信号传导通路,调节和控制细胞的生长、增殖、分化、迁移与凋亡,从而在癌变的发生和发展过程中发挥重要的作用。本文主要就LMP1的结构、生物学功能、介导的信号通路及其与肿瘤关系的相关进展做一阐述。
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| 关 键 词： | EB病毒 潜伏性膜蛋白1 肿瘤 |
Advancement of Epstein-Barr Virus-Encoded LMP1 in Tumor |
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| TANG Wei,ZHU Jian-si.Advancement of Epstein-Barr Virus-Encoded LMP1 in Tumor[J].Progress in Modern Biomedicine,2012,12(7):1394-1397. |
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| Authors: | TANG Wei ZHU Jian-si |
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| Institution: | (Cancer Research Institute,University of South China,Hengyang 421001,China) |
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| Abstract: | Epstein-Barr virus is a kind of herpes virus that has oncogenic potential and is related to the tumor genesis process of various malignancy.Epstein-Barr virus-encoded LMP1 plays an important role in the pathogenesis and development of cancer,which as the main oncogenic protein of EBV,through a variety of intracellular signal transduction pathways to regulate and control cell growth,proliferation,differentiation,migration and apoptosis.This article mainly reviews its structure,biological function,signaling pathway and the related progress with tumor. |
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| Keywords: | Epstein-Barr virus Latent membrane protein 1 Tumor |
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