具有中空贯通管结构的磷酸钙骨水泥的制备研究

目前,磷酸钙骨水泥因其具有优良的生物性能已被广泛用于骨组织工程,但它自固化后只是形成具有微孔和封闭气孔的致密块体,其孔径尺寸和连通性仍远达不到骨组织工程的最佳要求.本研究采用α-TCP为原料,以过氧化氢作为发泡剂,使用模具插针法制得一种具有大孔径和中空管的多孔磷酸钙骨水泥材料.孔径达到900μm,孔隙率为50.67%,抗折强度达到5.84MPa.通过扫描电镜照片观察和分析微观结构.结果表明,通过这种方法可以制得具有理想孔径尺寸和连通性的多孔磷酸钙骨水泥,可以说,这为制备用于骨组织工程的多孔磷酸钙骨水泥创造了一种新的方法.

Research on Preparation of Porous Calcium Phosphate Bone Cement with Hollow Tube Structure

At present,calcium phosphate bone cement has been widely used in bone tissue engineering for its excellent biological performances,but it just forms dense blocks after self-setting,with a kind of microporous structure and closed pores,whose pore size and interconnectivity are still far from the best requirements of bone tissue engineering.This study used a -TCP as raw materials and H2O2 as foaming agent,achieved a type of porous calcium phosphate bone cement materials with large aperture and hollow tubes by a method of inserting needles in the molds.Pore diameter reached 900?m,porosity was 50.67%,and flexural strength reached 5.84MPa.Photos of SEM were taken to observe and analyze the microstructure.The results showed that porous calcium phosphate bone cement with ideal pore size and interconnectivity can be fabricated by this method,which may create a new way for the preparation of porous calcium phosphate bone cement for bone tissue engineering.