不同时间点测定急性脑梗死患者的血浆促肾上腺皮质激素和皮质醇的临床意义

目的:检测急性脑梗死患者在不同时间点的血浆促肾上腺皮质激素和皮质醇,观察并分析测定结果,探讨血浆促肾上腺皮质激素和皮质醇含量的变化对急性脑梗死判断及预后的临床意义。方法:选择我院2011年5月至2013年6月收治的75例急性脑梗死患者为观察组,另选75位健康志愿者为对照组。采用电化学发光法测定两组不同时间点的血浆促肾上腺皮质激素和皮质醇含量,分析检测结果。结果:观察组患者在8时、16时、24时的血浆促肾上腺皮质激素和皮质醇水平均明显高于对照组,差异明显且具有统计学意义(P0.05);观察组中,预后好的患者不同时间点的血浆促肾上腺皮质激素和皮质醇明显低于预后差的患者,差异具有统计学意义(P0.05)。结论:不同时间点测定急性脑梗死患者的血浆促肾上腺皮质激素和皮质醇,对病情的判断及预后具有重要的临床意义。

Clinical Significance of Detecting the Plasma Adrenocorticotropic Hormone and Cortisol of Patientswith Acute Cerebral Infarction at Different Time Points

Objective:To detect the plasma adrenocorticotropic hormone and cortisol of patients with the acute cerebral infarction at different time so as to explore the clinical significance for the diagnosis and prognosis of the disease.Methods:Seventy-five patients with the acute cerebral infarction who were treated in our hospital from May 2011 to June 2013 were selected as the observation group, while another seventy-five healthy people who were taken the examination in our hospital were chosen to be the control group. Then the plasma adrenocorticotropic hormone and the cortisol levels were detected at different time points by means of the electro-chemiluminescence immunoassay. The changes of concentrations of plasma adrenocorticotropic hormone and cortisol of patients were observed and analyzed.Results:The plasma adrenocorticotropic hormone and cortisol at 8:00, 16:00 and 0:00 o''clock of patients in the observation group were higher than those of the patients in the control group with statistically significant differences (P<0.05); In the observation group, in terms of the levels of plasma adrenocorticotropic hormone and cortisol of patients with the acute cerebral infarction patients at different time, the detective results of patients with good prognosis were lower than those of the ones with bad prognosis with statistically significant differences (P<0.05).Conclusion:The detection of plasma adrenocorticotropic hormone and cortisol at different time points is important for clinical because it could help to determine the condition and prognosis of acute cerebral infarction.