不同程度骨创伤患者的血浆D-D水平和血糖的变化及临床意义

目的:探讨不同程度骨创伤患者的血浆D-D水平和血糖水平的变化的临床意义,为骨损伤预后和病情判断提供参考依据。方法:选取符合标准的骨创伤患者260例,健康体检者260例,分别为观察组和对照组组,监测并比较观察组患者入院第1、3、5、7天及健康体检者血浆中D-D和血糖水平。结果:观察组的D-D和血糖水平显著高于健康对照组,差异有统计学意义(P0.05);观察组的各个时间D-D和血糖水平,特重伤组高于重伤组,重伤组高于轻伤组,比较差异有统计学意义(P0.05);血浆中D-D水平与血糖水平与骨创伤的严重程度呈正相关(r=0.73,P0.05;r=0.82,P0.05)。结论:骨创伤越严重血糖和D-D水平越高,临床上可以将两中生物标记物作为评断骨创伤患者的严重程度和预后情况的指标。

Clinical Significance of D-dimer Levels and Blood Glucose in Patients With Bone Trauma of Different Degrees

Objective:To study clinical significance of D-dimer levels and blood glucose in patients with different degrees of bone trauma, and to provide a reference for prognosis of bone injury and illness judgment.Methods:60 cases of patients with bone trauma and 260 cases of healthy patients undergoing physical examination were selected as observation group and healthy group respectively, the plasma levels of D-D and blood glucose of two groups of patients were monitored and compared at day1, 3, 5, 7 in hospital stay.Results:The D-dimer and blood glucose levels of the observation group were significantly higher than that of the control group, the difference was statistically significant (P<0.05); The D-dimer and blood glucose of particularly serious injury group was higher than that of serious injury group, and, it was higher in serious injury group than in slight injury group, the difference was statistically significant (P<0.05); D-dimer levels and blood glucose levels in plasma were positively associated with the severity of the bone trauma (r =0.73, P<0.05 and r=0.82, P< 0.05).Conclusion:The more serious the bone trauma is, the higher blood glucose and D-dimer levels can be; Two clinical biomarkers can be used to judge the severity and prognosis of patients with bone trauma.