珍芪降糖胶囊对糖尿病大鼠的药效学研究

目的：研究珍芪降糖胶囊对实验性糖尿病大鼠的治疗效果。方法：采用腹腔注射链脲佐菌素（STZ）制备糖尿病大鼠模型，观察珍芪降糖胶囊对大鼠血糖、胰岛素、血脂、尿素氮、肌酐、血小板聚集及肾小球形态的影响。结果：珍芪降糖胶囊能明显降低糖尿病大鼠的血糖、胰岛素含量，降低糖尿病大鼠低密度脂蛋白胆固醇、尿素氮、肌酐，提高高密度脂蛋白胆固醇含量，对二磷酸腺苷（ADP）诱导的大鼠血小板聚集有明显的抑制作用，并有减轻肾小球病变的作用。结论：珍芪降糖胶囊在降低血糖、调节脂质代谢紊乱、改善肾小球功能等多方面发挥较好的作用。

Study on pharmacodynamics effect of ZhenQijiangtang Capsule on diabetic rats

Objective: To study the therapeutic effect of ZhenQijiangtang Capsule on the diabetic rats.Methods: The models of 40 mice with diabetes were made by injecting Streptozotocin(STZ),the effect of ZhenQijiangtang Capsule on the blood glucose,insulin,blood fat,bun,creatinine,platelet aggregation(PA) and glomerular morphology of the mice were observed.Results: ZhenQijiangtang Capsule can obviously reduce the mouse's blood glucose,insulin and Low Density Lipoprotein Cholesterol)(LDL-c),bun,creatinine,improve high-density Lipoprotein cholesterol(HDL-C),restrain platelet aggregation caused by adenosine diphosphate(ADP),and lighten pathological changes of glomerulosclerosis.Conclusion: ZhenQijiangtang Capsule does better function in many ways,such as reducing blood glucose,adjusting lipid metabolic disturbance,and improving the function of glomerulosclerosis.