老年支气管哮喘患者血清MC-CP、Th17的表达及其与呼吸功能、肺功能的相关性分析

摘要 目的：探究老年支气管哮喘患者血清肥大细胞羧肽酶（MC-CP）、Th17表达及其与患者呼吸功能、肺功能的相关性。方法：选择2018年4月至2021年8月于中国人民解放军东部战区总医院接受治疗的120例老年支气管哮喘患者为研究组（SG），另选同期于我院接受治疗的100例支气管炎患者为对照组（CG），对比两组患者血清MC-CP、Th-17、呼气峰值流速（PEF）、第1秒用力呼气量（FEV₁）、血氧分压（PaO₂）、FEV₁占预计值的百分数（FEV₁/FVC）差异，就研究组患者MC-CP、Th-17水平与其呼吸功能、肺功能的相关性开展Spearman分析。结果：（1）研究组患者的MC-CP水平明显高于对照组，Th17百分比同样明显高于对照组（P<0.05）；（2）研究组患者的呼吸功能指标PEF、PaO₂，以及肺功能指标FEV₁、FEV₁/FVC均明显低于对照组（P<0.05）；（3）研究组患者MC-CP与PEF、PaO₂呈现明显负相关联系（r=-0.558、-0.700，P<0.001），研究组患者Th17与PEF、PaO₂呈现明显负相关联系（r=-0.695、-0.774，P<0.001）；（4）研究组患者MC-CP与FEV₁、FEV₁/FVC呈现明显负相关联系（r=-0.609、-0.481，P<0.001），研究组患者Th17与FEV₁、FEV₁/FVC呈现明显负相关联系（r=-0.622、-0.561，P<0.001）。结论：老年支气管哮喘患者血清MC-CP及Th17水平会出现异常升高状态，而呼吸功能与肺功能会出现降低，相关性分析显示此类患者血清MC-CP及Th17水平与其呼吸功能、肺功能均呈现负相关联系。

Expression of Serum Mc-cp and Th17 in Elderly Patients with Bronchial Asthma and Their Correlation with Respiratory Function and Pulmonary Function

ABSTRACT Objective: To investigate the expression of serum mast cell carboxypeptidase (mc-cp) and Th17 in elderly patients with bronchial asthma and their correlation with respiratory function and pulmonary function; Methods: 120 elderly patients with bronchial asthma who were treated in our hospital from April 2018 to August 2021 were selected as the study group (SG), and 100 patients with bronchitis who were treated in our hospital during the same period were selected as the matched group (CG). The differences in serum mc-cp, Th-17, peak expiratory flow rate (PEF), partial pressure of oxygen (PaO₂), FEV₁ and FEV₁/FVC were compared between the two groups, Spearman analysis was carried out on the correlation between the levels of mc-cp and Th-17 and their respiratory and pulmonary functions in the study group; Results: (1) the level of mc-cp in the study group was higher than that in the matched group, and the percentage of Th17 in the study group was also higher than that in the matched group (P<0.05); (2) PEF, PaO₂, FEV1 and FEV₁/FVC in the study group were lower than those in the matched group (P<0.05); (3) Mc-cp was negatively correlated with PEF and PaO₂ in the study group (r=-0.558, -0.700, P<0.001), and Th17 was negatively correlated with PEF and PaO₂ in the study group (r=-0.695, -0.774, P<0.001); (4) Mc-cp was negatively correlated with FEV₁ and FEV₁/FVC in the study group (r=-0.609, -0.481, P<0.001), and Th17 was negatively correlated with FEV₁ and FEV₁/FVC in the study group (r=-0.622, -0.561, P<0.001). Conclusion: the levels of serum mc-cp and Th17 in elderly patients with bronchial asthma will increase abnormally, while the respiratory function and pulmonary function will decrease. The correlation analysis shows that the levels of serum mc-cp and Th17 in these patients are negatively correlated with their respiratory function and pulmonary function.