神阙穴贴敷联合益生菌对重症脑卒中合并胃肠功能障碍患者血清胃肠激素和肠黏膜屏障指标的影响

摘要 目的：探讨神阙穴贴敷联合益生菌对重症脑卒中合并胃肠功能障碍患者的影响。方法：采用随机数字表法，将我院2021年3月~2022年2月期间收治的102例重症脑卒中合并胃肠功能障碍患者分为对照组（51例，益生菌治疗）和研究组（51例，神阙穴贴敷联合益生菌治疗）。观察两组疗效和用药安全性，对比两组临床指标、血清胃肠激素和肠黏膜屏障指标。结果：与对照组相比，研究组的临床总有效率进一步升高（P<0.05）。与对照组相比，研究组的肠鸣音恢复时间、肛门排气排便时间缩短（P<0.05）。与对照组相比，研究组治疗7 d后促胃液素（GAS）、促胃动素（MTL）更高（P<0.05）。与对照组相比，研究组治疗7 d后生长抑素（SS）更低（P<0.05）。与对照组相比，研究组治疗7 d后内毒素（ET）、二胺氧化酶（DAO）、D-乳酸更低（P<0.05）。两组均未见明显的不良反应发生。结论：神阙穴贴敷联合益生菌治疗重症脑卒中合并胃肠功能障碍患者，可改善血清胃肠激素和肠黏膜屏障指标，缩短肛门排气排便时间、肠鸣音恢复时间，有效改善患者临床症状。

Effect of Shenque Acupoint Application Combined with Probiotics on Serum Gastrointestinal Hormones and Intestinal Mucosal Barrier Indexes in Patients with Severe Stroke Complicated with Gastrointestinal Dysfunction

ABSTRACT Objective: To explore the effect of Shenque acupoint application combined with probiotics on patients with severe stroke complicated with gastrointestinal dysfunction. Methods: Using random number table method, 102 patients with severe stroke complicated with gastrointestinal dysfunction who were admitted to our hospital from March 2021 to February 2022 were divided into control group (51 cases, probiotics treatment) and study group (51 cases, Shenque acupoint application combined with probiotics treatment). The efficacy and drug safety of the two groups were observed, and the clinical indexes, serum gastrointestinal hormone and intestinal mucosal barrier indexes of the two groups were compared. Results: Compared with the control group, the total clinical effective rate of the study group was further increased (P<0.05). Compared with the control group, the bowel sound recovery time and anal exhaust and defecation time of the study group were shortened (P<0.05). Compared with the control group, the levels of gastrin (GAS) and motilin (MTL) of the study group at 7 d after treatment were higher (P<0.05). Compared with the control group, somatostatin (SS) of the study group at 7 d after treatment was lower (P<0.05). Compared with the control group, endotoxin (ET), diamine oxidase (DAO) and D-lactic acid of the study group at 7 d after treatment were lower (P<0.05). There were no obvious adverse reactions in the two groups. Conclusion: Shenque acupoint application combined with probiotics in the treatment of patients with severe stroke complicated with gastrointestinal dysfunction can improve the indicators of serum gastrointestinal hormones and intestinal mucosal barrier, shorten anal exhaust and defecation time, and the bowel sound recovery time, and effectively improve the clinical symptoms of patients.