北京市2型糖尿病患者抑郁状况的横断面调查及其危险因素分析

目的:探讨北京市2型糖尿病(T2DM)患者抑郁症发病情况及其危险因素,为T2DM合并抑郁症的防治提供依据。方法:采取横断面调查的方法对2016年1月-2016年12月中国人民解放军总医院健康管理研究院体检中患T2DM的3000例患者随机抽取1200例进行调查,所有患者进行Zung抑郁自评量表(SDS)测评,根据SDS结果分为T2DM合并抑郁症组和T2DM非抑郁症组。应用单因素和多因素Logistic回归法分析T2DM合并抑郁症的危险因素。结果:北京市T2DM患者抑郁症患病率为21.93%,不同性别T2DM患者抑郁症患病率比较无统计学差异(P0.05)。单因素分析显示,北京市T2DM患者抑郁症发病与糖尿病病程、运动情况、胰岛素治疗、并发症情况、糖化血红蛋白有关(P0.05),与饮食控制、血糖监测情况、收缩压、舒张压、胆固醇、甘油三酯无关(P0.05)。多因素Logistic回归分析显示糖尿病病程≥10年、胰岛素治疗、并发症≥3个、糖化血红蛋白≥8.0%是北京市T2DM患者抑郁症发病的危险因素(P0.05),经常运动是北京市T2DM患者抑郁症发病的保护性因素(P0.05)。结论:北京市T2DM患者抑郁症患病率为21.93%,糖尿病病程≥10年、胰岛素治疗、并发症≥3个、糖化血红蛋白≥8.0%是北京市T2DM患者抑郁症发病的危险因素,经常运动是北京市T2DM患者抑郁症发病的保护性因素。

Cross-Sectional Study and Risk Factors of Depression in Patients with Type 2 Diabetes Mellitus in Beijing

ABSTRACT Objective: To analyze the incidence of depression and its risk factors in patients with type 2 diabetes mellitus (T2DM) in Beijing, and to provide evidence for the prevention and treatment of T2DM associated with depression. Methods: A cross-sectional survey was conducted in 1200 patients randomly selected from 3000 patients with T2DM, who accepted the physical examinations in Health Management Institute of the General Hospital of PLA during January 2016 to December 2016. All the patients were evaluated by the Zung self rating Depression Scale (SDS), according to the results of SDS,the patients were divided into T2DM group with depression and T2DM group without depression. The risk factors of T2DM associated with depression were analyzed by Univariate and multivariate Logistic regression analysis. Results: The prevalence of depression in T2DM patients in Beijing city was 21.93%, and there was no signif- icant difference in the prevalence of depression among T2DM patients with different genders(P>0.05). Univariate analysis showed that the incidence of depression in T2DM patients in Beijing city was related to the course of diabetes, exercise, insulin treatment, complica- tions and glycosylated hemoglobin (P<0.05), and it was not related to diet control, blood glucose monitoring, systolic blood pressure, di- astolic blood pressure, cholesterol and triglyceride (P>0.05). Logistic regression analysis showed that the duration of diabetes more than 10 years, insulin treatment, complications of more than 3, glycated hemoglobin with more than 8.0% were risk factors of depression in T2DM patients in Beijing city(P<0.05). For T2DM patients in Beijing, regular exercise was a protective factor for the incidence of de- pression in T2DM patients in Beijing city(P<0.05). Conclusion: The prevalence of depression in T2DM patients in Beijing city was 21.93%, the duration of diabetes more than 10 years, insulinize treatment, complications of more than 3, glycated hemoglobin with more than 8.0% were risk factors of depression in T2DM patients in Beijing city, regular exercise was a protective factor of the incidence of de- pression in T2DM patients in Beijing city.