复方丹参滴丸联合阿司匹林对冠心病患者血小板聚集功能及血脂水平的影响

目的:探讨复方丹参滴丸联合阿司匹林对冠心病(CHD)患者血小板聚集功能及血脂水平的影响。方法:选取2011年10月到2016年12月在我院接受治疗的CHD患者320例作为本次研究对象,采用乱数表法将所有患者分为对照组和观察组各160例,两组患者均采用扩冠、抗凝和降压药物等常规内科治疗,在此基础上对照组给予阿司匹林治疗,观察组给予复方丹参滴丸联合阿司匹林治疗,两组均治疗6个月。对比两组临床疗效、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)及高密度脂蛋白(HDL)、血栓素B2(TXB2)水平,记录血小板最大聚集率(PAGM)及不良事件发生率。结果:治疗后观察组的总有效率为93.13%,显著高于对照组的68.75%(P0.05)。治疗6个月后观察组HDL水平高于治疗前和对照组,LDL、TC、TG水平低于治疗前和对照组(P0.05)。治疗6个月后两组患者PAGM、TXB2水平均有明显下降,且观察组PAGM、TXB2水平低于对照组(P0.05)。观察组不良事件发生率为2.50%,显著低于对照组的18.13%(P0.05)。结论:复方丹参滴丸与阿司匹林联合治疗CHD临床疗效较好,可以有效抑制血小板凝聚,调节血脂,降低不良事件发生率,值得在临床上推广。

Effect of Compound Danshen Dripping Pills Combined with Aspirin on Platelet Aggregation Function and Blood Lipid Level in Patients with Coronary Heart Disease

ABSTRACT Objective: To investigate the effect of Compound Danshen dripping pills combined with aspirin on platelet aggregation function and blood lipid level in patients with coronary heart disease (CHD). Methods: 320 patients with CHD treated in our hospital from October 2011 to December 2016 were selected as the subjects. All patients were divided into the control group and the observation group by random number table method, 160 cases in each group. Two groups of patients were treated with expanding crown, anticoagula- tion and antihypertensive drugs and other routine medical treatment, on this basis,the control group were treated with aspirin, and the ob- servation group were treated with Compound Danshen dripping pills combined with aspirin. The two groups were treated for 6 months. The clinical efficacy,triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and throm- boxane B2 (TXB2) levels between the two groups were compared. The maximum platelet aggregation rate (PAGM) and incidence of ad- verse events were recorded. Results: After treatment, the total effective rate of the observation group was 93.13%, which was significantly higher than 68.75% of the control group (P<0.05). 6 months after treatment, the levels of HDL in the observation group were higher than before treatment and control group, the levels of LDL, TC and TG were lower than before treatment and control group (P<0.05). 6 months after treatment, the levels of PAGM and TXB2 were significantly decreased in the two groups, and the levels of PAGM and TXB2 in the observation group were significantly lower than that in the control group (P<0.05). The incidence of adverse events in the observation group was 2.50%, which was significantly lower than 18.13% of the control group(P<0.05). Conclusion: Compound Danshen dripping pills combined with aspirin has good clinical efficacy in the treatment of CHD, can effectively inhibit platelet aggregation func- tion, regulate blood lipids, reduce the incidence of adverse reactions, it is worthy of clinical promotion.