反复呼吸道感染患儿血清微量元素及体液免疫水平测定及临床意义

目的:探讨反复呼吸道感染患儿血清微量元素及体液免疫水平测定及其临床意义。方法:选取2016年1月至2017年1月在我院接受治疗的反复呼吸道感染患儿64例作为观察组,另外选取同期来我院体检的健康儿童60例作为对照组,比较两组儿童血清微量元素钙(Ca)、铁(Fe)、铜(Cu)、锌(Zn)、镁(Mg)等的水平、体液免疫因子免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平及血清补体C3、C4、C5水平,并分析其相关性。结果:观察组患儿血清Ca、Fe、Zn水平显著低于对照组儿童(P0.05),两组儿童血清Cu、Mg水平比较差异无统计学意义(P0.05)。观察组患儿血清IgA、IgM、IgG水平低于对照组儿童(P0.05)。两组儿童血清补体C3、C4、C5水平比较差异无统计学意义(P0.05)。经Pearson相关性分析可得:反复呼吸道感染患儿血清Ca、Fe、Zn与血清IgA、IgM、IgG水平呈正相关(P0.05)。结论:反复呼吸道感染患儿存在血清Ca、Fe、Zn微量元素缺乏及血清IgA、IgM、IgG水平降低现象,且它们之间具有正相关关系,可能共同促进反复呼吸道感染的发生。

Children with Recurrent Respiratory Tract Infection: Determination and Clinical Significance of Serum Trace Elements and Humoral Immunity

ABSTRACT Objective: To investigate the determination and clinical significance of serum trace elements and humoral immunity in children with recurrent respiratory tract infection. Methods: A total of 64 children with recurrent respiratory tract infection, who were treated in Children''s Hospital of Shanghai from January 2016 to January 2017, were chosen as observation group;in addition,60 healthy children who received physical examination in this hospital, as control group during the same period.The levels of serum trace elements calcium (Ca), iron (Fe), copper (Cu), zinc (Zn) and magnesium (Mg),humoral immune factors of immunoglobulin A (IgA),immunoglobulin M (IgM), immunoglobulin G (IgG) levels, and serum levels of complement C3, C4, and C5 were compared between the two groups,and the correlation among them was analyzed. Results: The serum levels of Ca, Fe and Zn in the observation group were significantly lower than those in the control group (P<0.05). There was not statistically significant in serum Cu and Mg levels between the two groups (P>0.05). The serum levels of IgA, IgM and IgG in the observation group were significantly lower than those in the control group (P<0.05). There were not statistical differences in the levels of serum complement C3, C4 and C5 between the two groups (P>0.05).Pearson correlation analysis showed that the levels of serum Ca, Fe and Zn were positively related to serum IgA, IgM and IgG levels in children with repeated respiratory infection (P<0.05). Conclusion: Deficiency of trace elements in serum Ca, Fe and Zn and the decrease of serum IgA, IgM and IgG levels were found in children with recurrent respiratory tract infection,and there is a positive correlation between them, which may jointly promote the occurrence of recurrent respiratory tract infections.