血栓弹力图检测在卵巢过度刺激综合征中的应用

目的:研究血栓弹力图在卵巢过度刺激综合征(Ovarian Hyperstimulation Syndrome,OHSS)患者血凝块形成评价中的应用及临床意义。方法:将35例接受胚胎移植治疗后发生OHSS患者及21例同期治疗未发生OHSS患者,进行血栓弹力图(Thromboelastography,TEG)检测,同时收集常规凝血参数(凝血酶原时间(Prothrombin time,PT)、活化部分凝血活酶时间(Activated partial thromboplastin time,APTT)、纤维蛋白原(Fibrinogen,FIB)等)。分析OHSS患者与对照患者凝血和TEG各指标的差异,以及OHSS患者治疗前后TEG各指标的差异。结果:(1)OHSS患者PT时间明显高于对照组,FIB水平明显低于对照组,但APTT时间无明显区别(P=0.112);(2)TEG检测OHSS组的血凝综合指数明显高于对照组(3.6±0.7:0.8±0.5);(3)治疗后,OHSS患者血凝综合指数2.8±0.9,较治疗前明显下降(P0.01)。结论:TEG检测可用于OHSS患者凝血功能的评估。

Application of Thromboelastography in Ovarian Hyperstimulation Syndrome

ABSTRACT Objective: To explore application of thromboelastography (TEG) on clot formation evaluation of patients with Ovarian Hyperstimulation Syndrome (OHSS). Methods: A total of 35 patients with OHSS and 21 patients without OHSS after embryo transfer therapy were received TEG test and conventional coagulation parameters test, including prothrombin time (PT), activated partial throm- boplastin time (APTT), fibrinogen (FIB), etc. The change of conventional coagulation parameters and TEG indicators were analyzed be- tween OHSS and control groups, as well as before and after treatment in OHSS group. Results: (1) Comparing with control group, PT time was significantly higher, while FIB levels were significantly lower in OHSS group. However, no significant difference was found on APTT time (P=0.112). (2) TEG showed that the coagulation index (CI) of OHSS group was significantly higher than that of control group (3.6±0.7:0.8±0.5). (3) After treatment, the average CI of OHSS group was 2.8±0.9, which was significantly decreased than admission(P<0.01). Conclusion: TEG test might be used for the coagulation function evaluation in OHSS patients, and provided important evidence for prevention, judgment and treatment of thrombosis.