胃癌组织中Bag-1蛋白表达特点及与临床病理学特征、预后的关系

目的:探讨Bc1-2相联系的抗凋亡基因1(Bag-1)蛋白在胃癌组织中的表达及与患者临床病理学特征、预后的关系。方法:选取病理科收集的79例胃癌组织及30例癌旁组织,标本收集时间2010年2月至2013年12月,采用免疫组化SP染色检测两组标本中的Bag-1蛋白表达水平,并分析Bag-1蛋白表达与胃癌患者临床病理学、预后的关系。结果:胃癌组织中的Bag-1蛋白阳性表达率65.82%显著的高于癌旁组织的13.33%(P0.05);Bag-1蛋白阳性表达的胃癌患者3年生存率30.77%显著的低于阴性表达患者的55.56%(P0.05);Bag-1蛋白阳性和阴性表达的患者1年以及2年生存率相差不大,差异无统计学意义(P0.05);Bag-1蛋白阳性表达的胃癌患者3年生存率30.77%显著的低于阴性表达患者的55.56%(P0.05)。结论:胃癌组织中的Bag-1蛋白高表达,并且与患者的胃癌临床分期和淋巴结转移以及预后有关。

The Relationship between the Expression of Bag-1 Protein and the Occurrence, Development and Prognosis of Gastric Carcinoma

ABSTRACT Objective: To investigate the expression of Bc1-2 related anti apoptosis gene 1 (Bag-1) protein in gastric carcinoma and its relationship with clinicopathological features and prognosis of the patients. Methods: Selection of Pathology, collected 79 cases of gastric carcinoma and 30 cases of adjacent tissue samples were collected from February 2010 to December 2013, by using SP immunohistochemical staining in two groups. The expression level of Bag-1 protein, and analyze the relationship between Bag-1 protein expression and clinical pathology in patients with gastric cancer and prognosis. Results: The positive expression of Bag-1 protein in gastric cancer rate of 65.82% was significantly higher than that in the adjacent tissues 13.33% (P<0.05); lower than the negative expression of Bag-1 protein expression in gastric cancer patients 3 year survival rate of 30.77% patients was 55.56% (P<0.05); the expression of Bag-1 and negative expression in 1 years, 2 years survival rate difference statistical significance (P>0.05); lower than the negative expression of Bag-1 protein expression in gastric cancer patients 3 year survival rate of 30.77% patients was 55.56% (P<0.05). Conclusion: High expression of Bag-1 protein in gastric cancer tissues is related to the clinical stage, lymph node metastasis and prognosis of gastric cancer.