化疗对乳腺癌患者激素水平及月经状态的影响

目的:讨论乳腺癌患者术后辅助化疗对患者激素水平及月经状况的影响。方法:收集我院2014年1月-2015年8月初诊绝经前乳腺癌患者78例,绝经后乳腺癌患者50例,检测化疗前及化疗结束后的雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)水平,随访绝经前乳腺癌患者化疗期间及化疗后月经变化情况。结果:绝经前乳腺癌患者化疗后E2水平明显下降,FSH、LH水平明显升高,差异具有统计学意义(P0.05),绝经后乳腺癌患者化疗后E2水平无明显变化(P0.05),FSH、LH水平均下降,差异具有统计学意义(P0.05)。绝经前乳腺癌患者三个不同年龄段化疗后E2水平降低,而FSH、LH水平升高,差异具有统计学意义(P0.05),但三个不同年龄段患者化疗前后性激素水平组间比较均无统计学差异(P0.05)。绝经前乳腺癌患者三个不同年龄段化疗后闭经率比较差异具有统计学意义(P0.05)。绝经前乳腺癌患者化疗后闭经患者E2水平明显低于未闭经患者,FSH、LH水平明显高于未闭经患者,差异具有统计学意义(P0.05)。结论:化疗可影响乳腺癌患者E2、FSH、LH水平,导致患者闭经,闭经情况与患者年龄有关。

Effect of Chemotherapy on Hormone Levels and Menstrual Status in Patients with Breast Cancer

ABSTRACT Objective: To study the effect of adjuvant chemotherapy on hormone levels and menstrual status in patients with breast cancer. Methods: A total of 78 premenopausal women and 50 postmenopausal women, who were diagnosed as breast cancer in Second People''s Hospital of Yibin from January 2014 to August 2015, were collected. The levels of estradiol (E2), luteinizing hormone (LH), fol- licle-stimulating hormone (FSH) of all the patients were detected before and after chemotherapy. The menstrual changes of pre- menopausal patients with breast cancer during chemotherapy and after chemotherapy were followed up. Results: After chemotherapy, the levels of E2 were significantly decreased in premenopausal breast cancer patients, while the levels of FSH and LH were significantly in- creased, the differences were statistically significant(P<0.05). There was no significant change in the levels of E2 after chemotherapy in postmenopausal breast cancer patients (P>0.05), but the levels of FSH and LH were significantly decreased, the differences were statisti- cally significant (P<0.05). After chemotherapy, the levels of E2 were decreased and the levels of FSH and LH were increased in three dif- ferent ages of premenopausal breast cancer patients, the differences were statistically significant (P<0.05); but there was no significant difference in sex hormone levels among them before and after chemotherapy (P>0.05). There was significant difference in amenorrhea rate after chemotherapy among the three different ages of premenopausal breast cancer patients(P<0.05). The levels of E2 in pre- menopausal patients with amenorrhea after chemotherapy were significantly lower than that in patients without amenorrhea, and the lev- els of FSH and LH were significantly higher than those without amenorrhea, and the difference was statistically significant (P<0.05). Conclusion: Chemotherapy can affect the levels of E2, FSH and LH in the patients with breast cancer, and can lead to amenorrhea, and amenorrhea is related to the age of the patients.