B7-H1和B7-H4在口腔鳞状细胞癌组织中的表达及临床意义

目的:探讨口腔鳞状细胞癌(Oral Squamous Cell Carcinoma,OSCC)中B7-H1和B7-H4的表达及其临床意义,并为OSCC的临床诊断、治疗、判断预后及预防等提供依据。方法:采用免疫组织化学S-P法检测B7-H1及B7-H4在60例OSCC及20例非肿瘤患者正常口腔黏膜组织(NOM)中的表达情况,分析两者与OSCC临床病理特征的相关性。结果:B7-H1在OSCC组织中表达显著高于在NOM组织中表达(29例,48.3%v4例,20%,x~2=4.969,P0.05);B7-H4在OSCC组织中表达亦显著高于在NOM组织中表达(31例,51.7%v5例,25%,x~2=4.310,P0.05)。B7-H1与B7-H4在OSCC组织的表达都与TNM分期、淋巴结转移和肿瘤分化程度显著相关(P0.05),而与年龄、性别及肿瘤直径大小等无关。OSCC组织中B7-H1和B7-H4的高表达呈显著性正相关性(x~2=5.613 P0.05),60例组织中B7-H1和B7-H4共表达现象有11例(18.3%),NOM中未发现两者共表达现象。结论:B7-H1和B7-H4过表达与OSCC发生、发展及预后有关,可以作为预后指标。

Expression and Clinical Significance of B7-H1 and B7-H4 in Oral Squamous Cell Carcinoma Tissues

ABSTRACT Objective: To explore the expression of B7-H1 and B7-H4 in Oral Squamous Cell Carcinoma (OSCC) and its clinical significance, and provide the basis for clinical diagnosis, treatment, prognosis and prevention of OSCC. Methods: Using immunohisto- chemical S - P method to detect B7 - H1 and B7 - H4 in 60 patients with OSCC and 20 cases of tumor expression innormal oral mucosa tissues(NOM), and the correlation with clinical pathological characteristics of OSCC are analyzed. Results: The expression ofB7-H1 in OSCC was significantly higher than that in the NOM group (29 cases, 48.3% v4, 20%, x²=4.969, P<0.05). The expression of B7-H4 in OSCC was also significantly higher than that in the NOM group (31 cases, 51.7% v5, 25%, x²=4.310, P<0.05). The expression of B7-H1 and B7-H4 in OSCC was significantly correlated with TNM staging, lymph node metastasis and tumor differentiation(P<0.05), regardless of age, sex and tumor diameter. The high expression of B7-H1 and B7-H4 in OSCC tissues showed significant positive correlation (x²=5.613 P<0.05). There were 11 cases (18.3%) in the total expression of B7-H1 and B7-H4 in the 60 cases, and no common expression was found in NOM. Conclusion: B7-H1 and B7-H4 overexpression are associated with the occurrence, development and prognosis of OSCC, which can be used as prognostic indicators.