阴道用乳杆菌活菌胶囊联合六味地黄汤治疗老年性阴道炎的临床效果和对血清性激素水平的影响

目的:研究阴道用乳杆菌活菌胶囊联合六味地黄汤治疗老年性阴道炎的临床效果和对血清激素水平的影响。方法:选择2015年1月~2016年12月在我院进行诊治的老年性阴道炎患者90例,随机分为两组。对照组采用阴道用乳杆菌活菌胶囊治疗,观察组联合采用六味地黄汤治疗。治疗一个月后,观察两组的临床治疗效果,检测两组患者治疗前后血清孕酮、雌二醇、促黄体生成激素以及促卵泡生成激素水平;并且随访1年,观察两组的复发情况。结果:治疗后,观察组的有效率为91.11%(41/45),明显高于对照组71.11%(32/45)](P0.05)。两组治疗前后的血清孕酮、雌二醇、促黄体生成激素以及促卵泡生成激素水平与治疗前相比差异均无明显差异(P0.05)。两组治疗期间均未出现明显的药物不良反应,观察组治疗后6个月、1年的复发率分别为4.44%(2/45)、11.11%(5/45),均明显低于对照组17.77%(8/45)、24.44%(11/45)](P0.05)。结论:阴道用乳杆菌活菌胶囊联合六味地黄汤可以有效提高老年性阴道炎的临床疗效,且不会影响机体的血清性激素水平丙可以有效降低其复发率。

Clinical Effect of Live Lactobacillus Capule for Vsginal Use Combined with Rehmanniae Decoction of Six Ingredients on theSenile Vaginitis and Its Influence on the Serum Sex Hormone Levels

ABSTRACT Objective: To investigate the clinical effect of live lactobacillus capule for Vsginal Use combined with Rehmanniae Decoction of Six Ingredients on the senile vaginitis and its influence on the serum sex hormone levels. Methods: 90 cases of patients with senile vaginitis who were treated in our hospital from January 2015 to December 2016 were selected and randomly divided into two groups, the control group was given Live Lactobacillus Capsule, the observation group was given Rehmanniae Decoction of Six Ingredients. The clinical efficacy, the serum progesterone, estradiol, luteinizing hormone and follicle-stimulating hormone levels and the recurrence of two groups were observed and compared. Results: After treatment, the effective rate of observation group was 91.11%(41/45), which was significantly higher than that of the control group(71.11%, P<0.05); the serum progesterone and estradiol, luteinizing hormone and follicle stimulating hormone levels of both groups showed no significant difference between two groups before and after treatment(P>0.05). At 6 months and 1 year after treatment, the recurrence rate of observation group was 4.44 %(2/45) and 11.11 %(5/45), which were significantly lower than those of the control group(17.77 %, 24.44%, P<0.05). Conclusion: Live Lactobacillus Capsule for Vsginal Use combined with Rehmanniae Decoction of Six Ingredients could effectively improve the clinical efficiency of senile vaginitis with no effect on the serum sex hormone levels, it could effectively reduce the recurrence rate.