微量元素五项联合红细胞四项检测在小儿缺铁性贫血中的诊断价值

目的:探讨微量元素五项联合红细胞四项检测在小儿缺铁性贫血(IDA)中的诊断价值。方法:选取2013年1月至2016年1月于我院进行治疗的小儿缺铁性贫血(IDA)患儿130例作为缺铁性贫血(IDA)组及同期于我院进行常规体检的健康儿童40例作为对照组。检测和比较其钙、镁、铜、铁、锌、血红蛋白(Hb)、平均红细胞体积(MCV)、平均血红蛋白含量(MCH)、平均血红蛋白浓度(MCHC)水平,并比较微量元素五项、红细胞四项检查以及两者联合对IDA患儿的诊断效能。结果:缺铁性贫血(IDA)组患儿微量元素镁、铁、锌含量以及Hb、MCV、MCH及MCHC水平均明显低于对照组儿童,差异具有统计学意义(P0.05);两组儿童微量元素钙、铜含量比较差异不显著(P0.05)。微量元素五项联合红细胞四项的灵敏度、特异度、阳性预测值及阴性预测值均明显高于微量元素五项和红细胞四项(P0.05)。结论:IDA患儿微量元素镁、铁、锌含量以及Hb、MCV、MCH及MCHC水平较低,微量元素五项联合红细胞四项检测可以提高小儿IDA的检出率。

Clinical Value of Five Trace Elements Combined with RBC Four Parameters Detection in Diagnosis of Children with IDA

ABSTRACT Objective: To explore the five trace elements and red blood cells (RBC) four parameters in diagnosis of children with iron deficiency anemia (IDA). Methods: Children with (130 cases) accepted in our hospital for treatment and 40 healthy children under- went physical exam from Jan, 2013 to Jan, 2016 were selected in this study. The expression level of five trace elements (Ca, Mg, Cu, Fe and Zn) and four RBC parameters (Hb, MCV, MCH and MCHC) were retrospectively analyzed. The positive prediction of five trace ele- ments, RBC four parameters and the combination detection for 130 children with IDA was compared. Results: The expression level of Mg, Fe, Zn, Hb, MCV, MCH and MCHC of children with IDA were significantly lower than that of control group (P<0.05), but the dif- ferences between the expression level of Ca and Cu of two groups had no significant significance (P>0.05); The sensitivity, specificity, positive predictive value and negative predictive value of the five combinations of micronutrients were significantly higher than that of micronutrients and erythrocytes(P<0.05). Conclusion: The expression level of Mg, Fe, Zn, Hb, MCV, MCH and MCHC of children with IDA were significantly lower than that of control group. Timely supplementation of trace elements magnesium, iron and zinc are impor- tant measures to prevent iron deficiency anemia (IDA). Five trace elements combined with RBC four parameters detection can improve the predictive rate of children with IDA and has important diagnostic value.