IL-17A在呼吸道慢性炎症性疾病中的研究进展

白介素-17A(IL-17A)是一种促炎因子,是IL-17细胞因子家族中的一员。该家族的细胞因子分别被命名为IL-17A至IL-17F,IL-17A是该家族中最具代表性的成员,它能够促进炎症细胞释放多种趋化因子、细胞因子和抗菌肽等,诱导中性粒细胞的聚集和增殖,是连接固有免疫和适应性免疫的桥梁。IL-17A的家族细胞因子在很多肺部过敏性、自身免疫性甚至肿瘤性疾病的发生发展和宿主防御中发挥着关键作用,在哮喘、慢性阻塞性肺病(COPD)、囊性纤维化(CF)、结节病、支气管扩张等呼吸道慢性炎症性疾病中均存在异常表达,虽然在多种疾病中未能阐明IL-17A影响疾病发展的具体作用机制,但已证明其水平与疾病的发展存在关联,这不仅为研究相关疾病的发病机制提供了新的切入点,也为其新型治疗手段的研究提供了新的思路。本文就IL-17A在呼吸道慢性炎症性疾病中的研究进展进行综述。

Research on IL-17A in Chronic Inflammatory Diseases of Respiratory Tract

ABSTRACT: Interleukin -17A (IL-17A) is a proinflammatory factor, it is a member of the IL-17 cytokine family. The cytokines in the family are named IL-17A to IL-17F, and IL -17A is the most representative member of the family. It can cause inflammatory cells to release a variety of chemokines, cytokines and antibacterial peptides and induce neutrophil aggregation and proliferation, which is a bridge between innate immunity and adaptive immunity. Cytokines in the IL-17A family play a key role in the development, develop- ment, and host defense of many lung allergic, autoimmune, and neoplastic diseases, and it is abnormally expressed in chronic inflamma- tory diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), sarcoidosis, bronchiectasis, and so on. Although the specific mechanism of IL-17A affecting disease development has not been elucidated in many diseases, it has been shown to be associated with the development of disease. It not only provides a new breakthrough point for the study of the pathogenesis of related diseases, but also provides a new way for the study of new treatment methods. This article reviews the progress in the study of IL-17A in chronic inflammatory diseases of respiratory tract.