强迫症的生物学机制和治疗综述

强迫症是以具有反复强迫思维和强迫行为为特征的一种心理障碍疾病。该病严重影响人们的心理健康和日常生活,因而受到广泛的关注。强迫症病因比较复杂,受到多种因素的影响,家庭环境、社会氛围、个人受教育程度、智力水平及个体的身体素质、健康状况及个性特点等因素与强迫症的产生密切相关。对强迫症的生物学机制的研究主要集中在对相关基因的研究上,其中五羟色胺和多巴胺在强迫症中的作用机制相对来说研究的比较多,也比较成熟,近年来又发现谷氨酸通路和白细胞介素-10也与强迫症的发生有关。与此同时一些治疗强迫症的方法也涌现了出来,如药物治疗和心理治疗。本文拟从强迫症的概念、临床表现、影响因素、生物学机制及其治疗方法等方面的研究进行阐述,以期为今后的研究提供一些参考和依据。

Review of Obsessive-Compulsive Disorder Biological Mechanism and Treatment

ABSTRACT: Obsessive-compulsive disorder(OCD) belong to one of psychogenic disorder, which is characterized by obsessional thoughts and obsessional behaviors. Many people are seriously affected by OCD in the mental health and daily life, and so far OCD is caused a extensive attention. The OCD etiology is involved many factors, such as family environment, social atmosphere, personal level of education, intelligence levels and the physical quality of the individual, health and personality traits. Research for obsessive-compul- sive disorder biological mechanism is mainly concentrated on some genes. Among those genes, 5-HT and DA research is relatively more and mature than others. In addition, recently it has been found that Glu and IL-10 are related to OCD. Meanwhile, OCD treatments are also emergence, especially medication treatment and psychotherapy. Mainly five aspects of OCD are given in this paper including the defini- tion, clinical manifestation, influencing factors, the biological mechanism and therapeutic methods, which may provide some valuable reference for correlative researches.