活性氧诱导心律失常的分子生物学机制研究

心律失常特别是室性心律失常可能导致心源性猝死,已经成为临床上常见和重点问题。多种原因可能诱发心律失常如:冠状动脉粥样硬化性心脏病,瓣膜病,肥厚性心肌病等心脏源性病变,很多代谢性物质改变也可能增加心律失常的发生概率。近年发现活性氧可能是诱发各种心律失常的一个重要因素,活性氧不仅参与重要离子通道和转运受体的调控,同时本身也作为一个重要的第二信来调节一些关键酶的活性如:蛋白激酶A(PKA),蛋白激酶C(PKC),钙离子依赖性蛋白激酶II(CaMKII)。最近有研究发现长期的活性氧代谢紊乱可能引起细胞遗传物质如miRNA的改变,引起长期的心律失常如房颤。本文主要对活性氧导致心律失常的可能机制做一总结,为心律失常的防治提供一些可能潜在方向。

The Reactive Oxygen Species Induced Molecular Mechanisms of Arrhythmia

ABSTRACT: Arrhythmias especially ventricular arrhythmias may lead to sudden cardiac death, it has become a common clinical problems and priorities. A variety of reasons may induce arrhythmias such as: coronary atherosclerotic heart disease, valvular heart disease, hypertrophic cardiomyopathy and other heart-borne disease, metabolic disturbance of some substances may raise arrhythmia risk. In recent years, some researchers found that reactive oxygen species may be an important factor in inducing arrhythmia, the reactive oxygen species not only take part in the regulation of ion channels and transporters, but also as second messengers to modulate some of the key enzymes such as: protein kinase A (PKA), protein kinase C (PKC), calcium-dependent protein kinase II (CaMKII). The latest studies have shown that chronic reactive oxygen species metabolic dysfunction may mediate abnormity of miRNA, inducing chronic arrhythmias such as atrial fibrillation. In this review, the possible mechanism of reactive oxygen species induced arrhythmia is summarized, which could provide some potentially directions for the prevention and treatment of cardiac arrhythmias.