血脂代谢指标及血清维生素A、E水平与子痫前期的相关性分析

目的:探讨血脂代谢指标及血清维生素A、E水平与子痫前期的相关性。方法:选取2016年12月至2017年12月期间来我院产检及住院分娩的722例妊娠妇女,选取94例子痫前期的妊娠妇女作为A组,其中轻度子痫前期32例作为A1组,重度子痫前期62例作为A2组,并从剩余的628例正常妊娠者中选取126例自愿参与本研究的妊娠妇女作为B组。收集并记录妊娠妇女的临床指标,包括入院时的孕周、孕次、产次、流产次数、血脂代谢指标、血清维生素A、E水平,分析血脂代谢指标、血清维生素A、E水平与子痫前期的相关性。结果:三组孕妇总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)、维生素A、维生素E水平整体比较差异均具有统计学意义(均P0.05);A1组、A2组的TC、TG、LDL、HDL、ApoA、ApoB、维生素A、维生素E水平与B组比较,差异均有统计学意义(均P0.05),A2组TG、LDL高于A1组,而维生素A、维生素E水平低于A1组,差异均有统计学意义(均P0.05),Spearman秩相关分析结果显示,TC、TG、LDL、ApoB水平与子痫前期呈正相关(r=0.214,0.432,0.517,0.226,P=0.012,0.008,0.005,0.012),HDL、ApoA、维生素A、维生素E水平与子痫前期呈负相关(r=-0.282,-0.357,-0.539,-1.217,P=0.010,0.009,0.003,0.000)。结论:血脂代谢指标、维生素A、维生素E水平在子痫前期孕妇中表达异常,且这些指标与子痫前期密切相关,应重视妊娠期孕妇的血脂代谢指标、维生素A、维生素E水平的监测,并控制其水平,从而有效防治子痫前期。

Correlation Analysis of Serum Lipids and Serum Vitamin A, E Levels with Preeclampsia during Pregnancy

ABSTRACT Objective: To investigate the correlation of serum lipids metabolism and serum vitamin A, E levels with preeclampsia during pregnancy. Methods: 722 pregnant women who came to our hospital for childbirth and hospitalization from December 2016 to December 2017 were selected. 94 pregnant women with preeclampsia were enrolled as group A, among them, 32 cases of mild preeclampsia was group A1, 62 cases of severe preeclampsia was group A2, 126 pregnant women who volunteered for the study were se- lected as the group B from the remaining 628 normal pregnant women. The clinical indexes of pregnant women, including gestational weeks, pregnancy times, production times, abortion times, blood lipid metabolism index, serum vitamin A and E levels on admission were collected and recorded, the correlation of lipid metabolism indicators, serum vitamins A and E between levels and preeclampsia were analyzed. Results: The differences of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipopro- tein (HDL), apolipoprotein A (ApoA), apolipoprotein B(ApoB), vitamin A and vitamin E among the three groups were statistically signif- icant (all P<0.05); The levels of TC, TG, LDL, HDL, ApoA, ApoB, vitamin A and vitamin E in group A1 and group A2 were significantly different from those in group B (all P<0.05). TG and LDL levels in group A2 were higher than those in group A1, but the levels of vita- min A and vitamin E were lower than group A1 (all P<0.05). Spearman rank correlation analysis showed that TC, TG, LDL and ApoB levels were positively correlated with preeclampsia (r=0.214, 0.432, 0.517, 0.226, P=0.012, 0.008, 0.005, 0.012). HDL, ApoA, vitamin A, and vitamin E levels were negatively correlated with preeclampsia (r=-0.282, -0.357, -0.539, -1.217, P=0.010, 0.009, 0.003, 0.000). Conclusion: The levels of indexes of blood lipid metabolism, vitamin A and vitamin E of preeclampsia pregnant women are abnormal, and these indicators are closely related to preeclampsia, the indicators of blood lipid metabolism, vitamin A and vitamin E in pregnant women should be emphasized, and the levels of these indicators should be effectively controlled, so as to effectively prevent the occurrence of preeclampsia.