| Orexin-A对大鼠胃功能的影响 |
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| 引用本文： | 田 彬,郝贺玲,杨丹丹,高胜利,徐 珞.Orexin-A对大鼠胃功能的影响[J].现代生物医学进展,2018(9):1633-1636. |
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| 作者姓名： | 田 彬 郝贺玲 杨丹丹 高胜利 徐 珞 |
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| 作者单位： | 青岛大学医学院病理生理学教研室;菏泽家政职业学院外科教研室 |
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| 基金项目： | 国家自然科学基金项目（81470815,81270460,81500414）；山东省优秀中青年科学基金项目（BS2014YY009）；青岛市科技局项目（14-2-3-3-nsh） |
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| 摘 要： | 目的:探讨Orexin-A对大鼠胃功能的影响。方法:通过大鼠迷走神经复合体微量注射Orexin-A后,观察大鼠胃运动、胃液和胃酸分泌的变化。结果:DVC微量注射Orexin-A后,大鼠胃收缩幅度以及收缩频率明显升高,且呈明显剂量依赖关系(P0.05),SB334867可显著阻断Orexin-A对促胃运动效应(P0.05)。DVC微量注射orexin-A后,大鼠胃液及胃酸分泌且呈剂量依赖性增加(P0.05)。结论:迷走神经复合体微量注射Orexin-A能影响胃的运动以及胃内体液的分泌。
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| 关 键 词： | Orexin-A 迷走神经复合体 胃运动 胃液 |
| 收稿时间： | 2017/5/28 0:00:00 |
| 修稿时间： | 2017/6/23 0:00:00 |
Effects of Orexin-A on the Stomach Function of Rats |
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| Abstract: | ABSTRACT Objective: To explore the effect of microinjection of orexin-A into vagal complex (DVC) on the gastric function of rats. Methods: Orexin-A was microinjected into the DVC, the changes of gastric motility and gastric juice or gastric acid secretion were observed. Results: After the microinjection of orexin-A into DVC, the amplitude and frequency of gastric motility were significantly increased in a dose-dependent manner. SB334867 prevented Orexin-A-induced changes of gastric motility(P<0.05). After the microinjec- tion of orexin-A into DVC, the secretion of gastric juice and gastric acid were significantly increased in a dose-dependent manner (P<0.05). Conclusion: Orexin-A could affect gastric motility and the secretion of gastric fluid. |
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| Keywords: | Orexin-A DVC Gastric motility Gastric fluid |
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