红藤养胃汤对胃癌患者血清MG7-Ag、TPS及OPN水平的影响

目的:探讨红藤养胃汤治疗胃癌的疗效及对血清胃癌相关抗原(MG7-Ag)、骨桥蛋白(OPN)、组织多肽特异性抗原(TPS)水平的影响。方法:选择2015年2月至2017年1月在我院进行胃癌治疗的86例患者,将其随机均分为观察组和对照组,每组43例。对照组患者给予奥美拉唑治疗,观察组患者在对照组基础上给予红藤养胃汤疗,比较两组患者的临床疗效,治疗前后血清MG7-Ag、TPS、OPN水平变化及不良反应的发生情况。结果:治疗后,观察组总有效率显著高于对照组,血清MG7-Ag、TPS、OPN水平均显著低于对照组,差异均具有统计学意义(P0.05),且恶心呕吐、发热及白细胞减少等不良反应的发生率显著低于对照组(P0.05)。结论:红藤养胃汤可显著提高胃癌患者的临床疗效,减少不良反应,有效降低患者血清MG7-Ag、TPS、OPN水平。

Effects of Hongteng Yangwei Decoction on Serum MG7-Ag, TPS and OPN Levels of Patients with Gastric Cancer

ABSTRACT Objective: To study the effect of Hongteng yangwei decoction on the serum MG7-Ag, OPN and TPS levels of patients with gastric cancer. Methods: 86 patients with gastric cancer treated in our hospital from February 2015 to January 2017 were randomly divided into the observation group and the control group. 43 patients in each group. The control groups was treated with omeprazole cap- sules, while the observation group of patients were additionally treated by Hong Teng Yangwei Decoction based on the control group. The clinical efficacy, serum MG7-Ag, TPS, OPN levels before and after treatment as well as the incidence of adverse reactions were compared between two groups. Results: After treatment, the total effective rate in the observation group was significantly higher than that of the control group, levels of serum MG7-Ag, TPS and OPN were significantly lower than those of the control group (P<0.05), the inci- dence of nausea and vomiting, fever, leucopenia, etc was significantly higher than that in the control group. Conclusion: Hongteng yang- wei decoction can enhance the clinical effect and decrease the adverse reactions on the gastric cancer patients, which may be related to reduce the serum MG7-Ag, TPS and OPN levels.