兰索拉唑与奥美拉唑治疗活动期胃溃疡的效果及对血清抗氧化因子的影响

目的:观察和比较兰索拉唑与奥美拉唑治疗活动期胃溃疡的临床效果及其对患者血清抗氧化因子水平的影响。方法:选取2016年1月至2017年1月我院收治的活动期胃溃疡患者88例,将其随机分成研究组和对照组,每组各44例。对照组给予奥美拉唑于睡前口服治疗,一次20mg,每日1次。研究组给予兰索拉唑于睡前口服治疗,一次30mg,每日1次。两组患者均以7d为一个疗程,连续治疗8个疗程。比较两组患者的临床总有效率和治疗前后血清超氧化物歧化酶(Superoxide dismutase,SOD)、丙二醛(Methylene dioxyamphetamine,MDA)、内皮素-1(Endothelin-1,ET-1)和一氧化氮(Nitric oxide,NO)水平的变化。结果:(1)研究组治疗总有效率为97.73%,对照组治疗总有效率为79.55%,研究组治疗总有效率显著高于对照组(P0.05);(2)治疗前,两组患者血清SOD、MDA、ET-1和NO水平比较差异无统计学意义(P0.05),研究组患者治疗后血清MDA、ET-1水平均明显低于对照组,血清SOD、NO水平均显著高于对照组(P0.05)。结论:兰索拉唑治疗活动期胃溃疡的临床效果明显优于奥美拉唑,可能与其显著提高患者血清SOD、NO水平及降低血清MDA、ET-1水平有关。

A Study on the Clinical Efficacy of Lansoprazole and Omeprazole in the Treatment of Active Gastric Ulcer and Effect on the Serum Antioxidant Factors

ABSTRACT Objective: To observe and compare the clinical efficacy of lansoprazole combined with omeprazole in the treatment of active gastric ulcer and effects on the serum antioxidant factors levels. Methods: 88 cases of patients with active gastric ulcer in our hos- pital admitted from January 2016 to January 2017 were selected and randomly divided into the study group and the control group, with 44 cases in each group. The control group was given omeprazole oral treatment before sleep, once 20 mg daily. The study group was given lansoprazole oral treatment before sleep, once 30mg daily. 7 days were as a course of treatment, both groups continuously treated for 8 courses. The clinical efficacy and serum SOD, MDA, ET-1 and NO levels before and after treatment were respectively observed and compared between the two groups. Results: (1) The total effective rate was 97.73% in the study group, which was significantly higher than that of the control group(79.55%, P<0.05). (2) There was no significant difference in the serum SOD, MDA, ET-1 and NO levels be- tween the two groups before treatment(P>0.05). After treatment, the levels of serum MDA and ET-1 in the study group were significantly lower than those in the control group, but the levels of serum SOD and NO in the study group were significantly higher than those in the control group (P<0.05). Conclusion: Lansoprazole had better clinical efficacy in the treament of active gastric ulcer compared with omeprazole, which may be attributed to the improvement of serum levels of SOD and NO, and reduction the serum levels of MDA and ET-1.