DTI定量参数对脑胶质瘤的诊断价值及其与血管内皮生长因子、细胞核增殖相关抗原的关系

目的:探讨扩散张量成像(DTI)定量参数对脑胶质瘤的诊断价值及其与血管内皮生长因子(VEGF)、细胞核增殖相关抗原(Ki-67)的关系。方法:选取2014年6月到2017年6月期间在我院接受治疗的90例脑胶质瘤患者,根据病理分级的不同分为中低级别组(n=46)和高级别组(n=44),比较两组患者表观扩散系数(ADC)值、各向异性分数(FA)值、相对表观扩散系数(rADC)值、相对各向异性分数(rFA)值、VEGF和Ki-67的阳性率,分析ADC值、FA值、rADC值、rFA值与VEGF、Ki-67表达的相关性。结果:高级别组的ADC值、FA值、rADC值和rFA值低于中低级别组(P0.05)。高级别组病理组织中VEGF、Ki-67的阳性表达率高于中低级别组(P0.05)。经Spearman相关分析显示,ADC值、FA值、rADC值和rFA值与VEGF、Ki-67的表达水平均呈负相关(P0.05)。结论:DTI定量参数与脑胶质瘤病理分级和VEGF、Ki-67的表达水平密切相关。

The Value of DTI Quantitative Parameters in the Diagnosis of Glioma and Its Relationship with Vascular Endothelial Growth Factor and Cell Nuclear Proliferation Related Antigen

ABSTRACT Objective: To investigate the diagnostic value of diffusion tensor imaging (DTI) quantitative parameters for glioma and its relationship with vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (Ki-67). Methods: 90 patients with glioma who were treated in our hospital from June 2014 to June 2017 were selected.According to the pathological grade, the patients were divided into the middle and low grade group (n=46) and the high grade group (n=44). The apparent diffusion coefficient (ADC) value, the anisotropy fraction (FA) value, the relative apparent diffusion coefficient (rADC) value, the relative anisotropy fraction (rFA) value,the positive rate of VEGF and Ki-67 were compared between the two groups. The correlation between ADC value, FA value, rADC value, rFA value and VEGF, Ki-67 expression was analyzed. Results: The ADC value, the FA value, the rADC value, and the rFA value of the high grade group are lower than the middle and low grade group (P<0.05). The positive expression rate of VEGF and Ki-67 in the patho- logical tissue of the high grade group was significantly higher than that in the middle and low grade group, and the difference was statisti- cally significant (P<0.05). Spearman correlation analysis showed that ADC value, FA value, rADC value and rFA value were negatively correlated with the expression levels of VEGF and Ki-67 (P<0.05). Conclusion: The quantitative parameters of DTI are closely related to the pathological grade of brain glioma and the expression levels of VEGF and Ki-67.