碱性成纤维生长因子(bFGF)对软骨生物学的影响

bFGF的生物学作用极其广泛,特别在促进创伤愈合与组织修复、组织再生起着十分重要的作用,它作为重要的有丝分裂促进因子,可传递发育的信号促进软骨细胞分裂,同时也是软骨细胞形态发生和分化的诱导因子,参与软骨的生长发育和组织损伤修复过程,特别是在软骨细胞的增殖分化起到重要作用,在解决软骨工程中面临的问题以及治疗骨关节炎等研究中具有的参考意义。本文对bFGF对软骨的分化、增殖、凋亡等不同生物学阶段的影响作用做一个综述。

Effect of bFGF on the Biological Properties of Cartilage

ABSTRACT:Basic fibroblast growth factor (bFGF) is an important promoting factor in mitosis. bFGF can be passed as the mesoderm and neural signal to promote the development of Ectodermal Dysplasia cell division, and cell morphogenesis and differentiation-inducing factor, growth and organizations involved in cartilage injury and repair process. Especially bFGF play an important role in proliferation and differentiation of chondrocytes which to provide reference value in solve the problem of tissue engineered cartilage and to cure osteoarthritis. This article makes a summary in effect of bFGF on the biological properties of cartilage, which is differentiation, proliferation, apoptosis.