慢性阻塞性肺疾病患者家庭长期氧疗的临床研究

目的：探讨家庭长期氧疗（LTOT）对慢性阻塞性肺疾病（COPD）患者的疗效。方法：将我院同期住院病人随机分为LTOT组（51人），对照组（52人）。全部病例在缓解期及治疗后每年测定PaO2、PaCO2、FVC、FEV1、HB、HCT的数值及每年住院次数。结果：①氧疗后1、2、3、4、5年与氧疗前比较，低氧血症改善，FEV1明显提高，HB、HCT明显减少；每年住院次数减少；②LTOT组5年生存率62．75％，对照组5年生存率46．15％，差异有显著性（p〈0．05）。结论：合理使用LTOT对COPD患者有良好的治疗作用，可提高患者的5年生存率。

Clinical research on domiciliary long- term oxygen therapy for patients with chronic obstructive pulmonary disease

Objective: To observe the therapeutic effect of domiciliary long-term oxygen therapy(LTOT)on patients with chronic obstructive pulmonary disease(COPD),with 5-year-survival rate.Methods: The patients,who were admitted to hospital during the corresponding period,were randomly divided into LTOT group(n=51) and control group(n=52).Values of PaO_2,PaCO_2,FVC,FEV_1,HB and HCT were examined at remission phase or annually after treatment,and admissions to emergency department were recorded.Results:(1) The admissions to emergency department,dyspnea,hypoxemia,index of lung function and arterial gas analysis were greatly improved after LTOT.(2) The 5-year survival rate(62.75%) in LTOT group was significantly more than that in control group(46.15%,p<0.05).Conclusion: The reasonable use of LTOT can achieve a good therapeutic effect on patients with COPD,which can improve their 5-year-survival rate.