曲美他嗪与稳心颗粒联合治疗不稳定性心绞痛疗效观察

目的:探讨曲美他嗪与稳心颗粒联合治疗不稳定性心绞痛临床疗效。方法:选取我院2011年6月-2012年6月不稳定性心绞痛患者150例,随机分为治疗组和对照组。对照组仅给予曲美他嗪治疗;治疗组给予曲美他嗪与稳心颗粒联合治疗。观察两组临床疗效、治疗前后心绞痛持续时间及发作次数、心电图改善情况及不良反应。结果:治疗组总有效率为86.8%,对照组总有效率为49.3%,两组疗效比较,差异具有统计学意义(P0.05);治疗组心电图总有效率为89.33%,对照组总有效率为72.00%,两组疗效比较,差异具有统计学意义(P0.05);治疗组心绞痛发作次数、持续时间、血液流变学指标较治疗前有显著下降(P0.05),较对照组有明显差异(P0.05)。两组患者治疗期间尿常规、血常规、肾功能、肝功能及电解质均未见明显变化,且两组患者不良反应差异无统计学意义(P0.05)。结论:曲美他嗪与稳心颗粒联合治疗不稳定性心绞痛临床疗效确切,具有很大临床意义。

Clinical Effects of the Trimetazidine Combined with Wenxin Grannle on the Treatment of Unstable Angina

Objective： To discuss the clinical effects of Trimetazidine combined with the Wenxin grannie on the treatment of unstable angina. Methods： 150 patients with unstable angina who were treated in our hospital from June 2011 to June 2012 were selected and randomly divided into the treatment group and the control group. The patients in the control group were only received the Trimetazidine treatment, while the patients in the treatment group were treated by the Trimetazidine combined with the Wenxin grannie. Then the clinical effects, the onset frequency and the persistence time of angina, the improvement of ECG and the incidence of adverse reactions were compared between two groups before and after the treatment. Results： The total effective rate was 86.8% in the treatment group of which in the control group was 49.3% with statistically significant difference （P〈0.05）; the total effective rate of ECG was 89.33% in the treatment group of which in the control group was 72.00% with statistically significant difference （P〈0.05）; there was significantly improvement on the onset frequency, the persistence time of angina and the hemodynamic indexes in treatment group after the treatment with statistically significant difference （P〈0.05）. There were no significant changes of the urine, the blood, the kidney and liver functions, the electrolytes and the adverse reactions between two groups （P〉0.05）. Conclusions： It is obvious that the clinical effects of the Trimetazidine combined with the Wenxin grannie on the treatment of the unstable angina.