酒石酸唑吡坦对非器质性失眠症患者Actigraphy检测指标的影响

目的:应用Actigraphy仪检测酒石酸唑吡坦对非器质性失眠患者睡眠质量的影响。方法:选择非器质性失眠症患者36例,实验第二晚给予10 mg酒石酸唑吡坦,实验第一晚和第四晚采用Actigraph仪监测,观察用药后Actigraph指标的变化。同时设置正常对照组24名,进行基础Actigraph监测。结果:失眠组患者服用酒石酸唑吡坦后,夜间Actigraphy检测显示实际觉醒时间(AWT)、睡眠潜入期(SL)、平均每次觉醒时间(MWB T)与服药前相比,显著缩短(P0.01);睡眠效率(SE)、平均静息状态时长(MLI)与服药前相比,显著提高(P0.01),同时反映身体活动的参数平均活动分数(MAS)和睡眠总体破碎程度的割裂指数(FI)与对照组相比,显著降低(P0.05)。结论:酒石酸唑吡坦能明显改善非器质性失眠患者睡眠,在非器质性失眠症的诊断治疗中Actigraphy仪是一种有效、便捷的方法。

Effect of Zolpidem Tartrate on Actigraphy Parameters in Patients with Insomnia

Objective： To investigate the effects of Zolpidem tartrate on sleep quality of patients with functional insomnia tested by Actigraphy sleep instrument. Methods： All the patients received 10 mg Zolpidem tartrate before sleep on the second night, and actigraphy sleep instrument was employed for 36 patients with insomnia on the first night and the fourth night, obtaining changes of Actigraphy parameters. Another 24 participants without insomnia were recruited as the control group and tested by Actigraphy sleep instrument. Results： Compared with the parameters before treatment of Zolpidem tartrate, many parameters changed significantly, including reduced actual wake time, sleep latency, mean wake bout time （P 〈 0.01）, and improved sleep efficiency, mean length immobility （P 〈 0.01）, and reduced mean activity score, fragmentation index （P 〈 0.05）. Conclusion： Zolpidem tartrate could significantly improve sleep quality of patients with fimctional insomnia, and Actigraphy sleep instrument was an effective and convenient tool in the diagnosis and treatment of patients with functional insomnia.