| 肝郁脾虚证模型大鼠血流变及TXB2、PGFla的变化 |
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| 引用本文： | 李艳彦,谢鸣,王洪海,陈禹.肝郁脾虚证模型大鼠血流变及TXB2、PGFla的变化[J].现代生物医学进展,2010,10(1). |
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| 作者姓名： | 李艳彦 谢鸣 王洪海 陈禹 |
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| 作者单位： | 1. 山西中医学院基础部方剂教研室,山西太原,030024
2. 北京中医药大学国家重点学科方剂学学科,北京,100029 |
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| 基金项目： | supported by Natural Fund of 211 Major Subject~~ |
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| 摘 要： | 目的:探查中医肝郁脾虚证模型的血流变及相关调节因子的状态。方法:采用慢性束缚应激+过度疲劳+饮食失节法建立大鼠肝郁脾虚证模型,测定大鼠造模三周、自然恢复一周时的血流变和血浆TXB2、PGF1a。结果:与正常组相比,模型组大鼠造模三周150/s、38/s、10/s、5/s切变率下的全血粘度、还原粘度均显著升高(P<0.001),红细胞聚集指数显著降低(P<0.001),红细胞压积显著升高(P<0.01),红细胞变形指数无显著性差异(P>0.05);血浆TXB2显著升高(P<0.001),6-keto-PGF1a显著降低(P<0.05),TXB2/PGF1a显著升高(P<0.01);模型组大鼠第四周150/s、38/s、10/s、5/s切变率下的全血粘度、还原粘度仍显著升高(P<0.001或P<0.01);红细胞聚集指数显著降低(P<0.001);红细胞压积与变形指数无显著性差异(P>0.05);血浆TXB2和TXB2/PGF1a显著降低(P<0.05),6-keto-PGF1a显著升高(P<0.05)。结论:肝郁脾虚证大鼠存在血液高粘和血栓易形成状态,恢复期血液高粘同时伴有扩血管因素的加强。提示肝郁脾虚证有血流...
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| 关 键 词： | 肝郁脾虚证 血流变 TXB2 PGF1a |
Change of Hemorheology and TXB2 and PGF1a in the Blood of the Rat with Liver-qi Stagnation and Spleen-qi Deficiency Syndrome |
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| LI Yan-yan,XIE Ming,WANG Hong-hai,CHEN Yu.Change of Hemorheology and TXB2 and PGF1a in the Blood of the Rat with Liver-qi Stagnation and Spleen-qi Deficiency Syndrome[J].Progress in Modern Biomedicine,2010,10(1). |
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| Authors: | LI Yan-yan XIE Ming WANG Hong-hai CHEN Yu |
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| Institution: | LI Yan-yan1,XIE Ming2,WANG Hong-hai2,CHEN Yu2(1 Shanxi University of Traditional Chinese Medicine,Taiyuan 030024,Shanxi Province,China 2 Beijing University of Chinese Medicine,Beijing 100029,China) |
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| Abstract: | Objective:To investigate the change of hemorheology and TXB2 and PGF1a in the TCM's syndrome model of GYPX(stagnation of liver-qi and deficiency of spleen-qi)made by a new compound method.Methods:Adopting chronic astriction,excess fatigue and improper diet on rats for constant three weeks and stopping treatment on them at the 4th week,determining the hemorheology and the contents of TXB2 and PGF1a in plasma of the rat of each group.Results:Compared with the normal group,the whole blood viscosity and reduced... |
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| Keywords: | syndrome of liver-qi stagnation and spleen-qi deficiency/syndrome of Ganyu Pixu(GYPX) hemorheology TXB2 PGF1a |
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