左卡尼汀配合复方玄驹胶囊对特发性少弱精子症的疗效观察

目的：观察复方玄驹胶囊联合左卡尼汀口服液治疗不同程度的特发性少弱精症的临床疗效。方法：选择2010年6月．2012年9月就诊于内蒙古医科大学第一附属医院的少弱精症者300例，其中重度少、弱精症者70例（治疗l组），中度少、弱精症者110例（治疗2组），轻度少、弱精症者120例（治疗3组）。另选择同期来我院进行健康体检者100例，将其作为对照纽。治疗组口服左卡尼汀口服溶液及复方玄驹胶囊，持续时间3个月。每一位被研究对象都在治疗前后定期进行血常规、尿常规、肝功能和肾功能四个方面的检查，同时观察服药患者在治疗过程中发生的不良反应。并对精液量、精子密度、A级精子等指标进行观察和比较。轻中度患者观察其（A＋B）级精子，重度患者观察其（B＋C）级精子，同时评价其治疗前后的生育能力，并与对照组比较。结果：与治疗前比较，治疗1、2、3组治疗后精液量（3．7±1．6、3．7±1．1、3．8±1．2）mL]、精子密度（3．4±1．4、23．2±1．8、39．6±14．2）（mol/L）]、A级精子（3．6±2．5、15．6±6.3、28．6±9．6）％]、（A＋B）级精子、（B＋C）级精子比例、生育力指数（0．2±0．0、0．8±0．1、1．4±0．1）均升高明显，差异显著（P〈0．05）；与对照组比较，治疗1、2、3组治疗前均有所减少，治疗1、2组治疗后虽有所上升，但还是显著低于对照组（P〈0．05），治疗3组治疗后与对照组差异不大，提示该方法对轻度少、弱精症者效果较重、中度好。结论：左卡尼汀配合复方玄驹胶囊对特发性少弱精子症效果显著。

Curative Effect Observation of L-camitine Less Coordination Compound XuanJu Capsule on Idiopathic Weak Spermatozoon Disease

Objective： To observe the curative effect observation of L-carnitine less coordination compound XuanJu capsule on idiopathic weak spermatozoon disease. Methods： 300 cases of less weak sperm disease from February 2010 to July 2012 in the first affili- ated hospital of Inner Mongolia medical university were selected, including less heavy and weak sperm disease （treatment group 1, 70 cases）, moderate, weak sperm disease （treatment group 2, 110 cases）, slightly less, weak sperm disease （treatment group 3, 120 cases）. 100 cases of healthy were checked-up as control group by the other options at the same time in our hospital. The treatment group were given L-carnitine and compound XuanJu capsules oral solution by oral for 3 months. All the research object in the before and after treat- ment regularly were checked blood routine, urine routine, liver, kidney, observe adverse reactions occurred in the process of treatment. Comparative observation indexes including A grade sperm quantity, sperm density, sperm, mild-to-moderate patients （grade A＋B） were observed sperm, severe group were observed （grade B＋C） sperm, at the same time more fertility evaluation before and after the treatment, and compared with the control group. Results： Compared with before treatment, semen volume （3.7± 1.6, 3.7± 1.1, 3.8± 1.2） mL], sp- erm density（3.4± 1.4, 23.2± 1.8, 39.6± 14.2）（mol/L）], grade A sperm （3.6± 2.5, 15.6± 6.3, 28.6± 9.6）%], sperm （A＋B）, （B＋C） grade sperm percentage, fertility index （0.2± 0.0, 0.8± 0.1, 1.4± 0.1） increased significantly in the treatment group of 1, 2, 3, the significant difference （P 〈 0.05）; Compared with control group, treatment 1, 2, 3 groups before treatment decreased, the treatment group after treatment 1 and 2 were rising, but were still significantly lower than control group （P 〈 0.05）, the difference in the three groups after treat- ment was not big compared with the control group, indicating that this method was good for weak sperm disease, compared with moderate and mild. Conclusion： The effect of L-carnitine less coordination compound XuanJu capsule on idiopathic weak spermatozoon disease is remarkable.