脑梗死患者血浆纤维蛋白原水平与颈动脉粥样硬化的关系

目的：探讨脑梗死患者血浆纤维蛋白原（Human Fibrinogen，Fro）水平的改变与颈动脉粥样硬化（CAS）的关系。方法：选取2009年5月-2012年6月入住解放军八一医院神经内科脑梗死患者508例。采用彩色多普勒超声检测脑梗死患者颈内动脉颅外段（／ntemalcarotidartery，ICA）、总动脉（common carotid artery，CCA）、颈总动脉分叉处内一中膜厚度（Intima—medial Thickness，IMT）。评定标准：颈动脉IMT〉0．9toni或（和）颈动脉斑决定义为CAS。24h内将患者空腹静脉血送检，记录测定后的生化指标及№水平，记录吸烟史、糖尿痛、高血压病等病史，采用Logistic回归分析测定的相关危险因素对颈动脉粥样硬化的作用强度。结果：按FIB水平分组（FIB≤3g／L组、FIB〉3g／L组），Logistic回归分析显示FIB〉3g／L组的危险度为2．04，年龄、FIB水平、高血压病史及吸烟史对CAS有影响，差异有统计学意义（P〈0．05），其中FIB与CAS的相关性最强。结论：FIB水平与脑梗死患者CAS的发展密切相关，其作用可能强于其他的传统危险因素。

Relationship between the Level of Fibrinogen and Carotid Atherosclerosis in Patients with Cerebral Infarction

Objective： To investigate the association between the level of Human fibrinogen and carotidatherosclerosis （CAS） as well as the effect of relevant risk factors on CAS. Methods： Carotid intima-media thickness （IMT） was measured using COlOr Doppler ultrasonography in 508 patients with cerebral infarction from May 2009 to June 2012 in the department of Internal Medicine, the people＇s Liberation Army eight one hospital. According to the results of ultrasonography, the patients were divided into two groups： normal （IMT ~〈 0.9 ram） and carotid atherosclerosis （IMT〉0.9 mm and plaque）. The plasma fibrinogen and other biochemical markers were also detected. The history of hypertension, diabetes, and smoking were also recorded. Results： According to the level of fibrinogen, patients were divided into two groups： ≤ 3 g/L group and 〉3 g/L group. Logistic regression showed that the rate of 〉3 g / L group was 2.04. There were significant differences in age, fibrinogen, hypertension, and smoking between the normal -carotid group and the carotid atherosclerosis group. Logistic regression showed that age, fibrinogen, hypertension, and smoking had significant influence on the CAS with the highest risk factor being the fibrinogen. Plasma fibrinogen was higher in lacunar infarction patients. Conclusion： In patients with cerebral infarction, the elevated plasma fibrinogen was significantly correlated with CAS. Therefore, ibrinogen might play more important role than other traditional risk factors.