HTR2A基因多态性与云南彝族酒精依赖关联性研究

目的：探讨酒精依赖和云南彝族5-羟色胺2A受体（HTR2A）基因多态之间的关系。方法：采用PCR-RFLP技术对330健康人（对照组）和110名酒精依赖者（病例组）的5-HT2A受体基因的遗传多态性进行检测。结果：在440例样本中共检测到2种等位基因A和G，三种基因型AA，AG，GG．三种基因型在对照组中频率分别是38．5％，55．8％，5．8％；在病例组中的频率分别是30％，63．6％，6．4％。结论：在云彝族人群中，HTR2A基因rs6311（A－1438G）位点与酒精依赖无显著关联，HTR2A基因rs6311（A-1438G）位点在云南汉族和云南彝族酒精依赖组中无显著差异，但是在健康对照组中存在关联性．

Association Study of Human Serotonin 5-HTR2A gene Polymorphisms with Alcohol Dependence in Yunnan Yi Population

Objective： To investigate the relationship between alcohol dependence and polymorphism of serotonin receptor 2 a （5-HTR2A） gene rs6311 in Yunnan Yi population. Methods： The PCR-RFLP was used to analyze genetic polymorphism of 5-HT2AR gene, the genotype and gene frequencies in 330 control groups and 110 AD groups. Results： Two alleles of the 5-HT2AR gene were detected in 440 samples： alleles A and G., including three genotypes： AA, AG and GG. Genotype frequency was 30%, 63.6%, 6.4% in AD groups, and 38.5%, 55.8%, 5.8% in control groups, respectively. Conclusion： There was no significant association for HTR2A gene rs6311 between AD group and control group in Yunnan Yi Population.