| 骨髓间质干细胞移植治疗大鼠脑出血模型的实验研究 |
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| 引用本文： | 戴杰陈蓝黄志东黄怀宇.骨髓间质干细胞移植治疗大鼠脑出血模型的实验研究[J].现代生物医学进展,2011,11(21):4030-4032. |
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| 作者姓名： | 戴杰陈蓝黄志东黄怀宇 |
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| 作者单位： | 南通大学第二附属医院,南通市第一人民医院神经内科 江苏南通,226001 |
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| 摘 要： | 目的:研究大鼠骨髓间质干细胞(MSCs)移植治疗脑出血的可行性。方法:分离MSCs后,连续传代培养、扩增,Brdu标记的MSCs通过颈动脉、侧脑室2种途径移植入脑出血大鼠模型体内,采用爬行计分法评估神经功能的恢复程度,并观察脑部Brdu阳性细胞的分布。结果:通过侧脑室、颈动脉移植后大鼠神经功能改善,明显优于对照组(P<0.05);经颈动脉注射组较经侧脑室注射组爬杆实验评分低(P<0.05)。移植的MSCs主要迁移到出血灶、大脑皮层、海马区等处。结论:MSCs移植对脑出血具有保护作用,而经颈动脉给药疗效优于经侧脑室给药。
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| 关 键 词： | 脑出血 骨髓间充质干细胞 移植 |
Experimental Study of Bone Marrow Stem Cells Administration in Rats
with Intracerebral Hemorrhage |
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| DAI Jie,CHEN Lan,HUANG Zhi-dong,HUANG Huai-Yu.Experimental Study of Bone Marrow Stem Cells Administration in Rats
with Intracerebral Hemorrhage[J].Progress in Modern Biomedicine,2011,11(21):4030-4032. |
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| Authors: | DAI Jie CHEN Lan HUANG Zhi-dong HUANG Huai-Yu |
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| Institution: | DAI Jie,CHEN Lan,HUANG Zhi-dong,HUANG Huai-Yu(Department of Neurology,Nantong First People's Hospital,the Second Affiliated Hospital of Nantong University,Nantong 226001) |
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| Abstract: | Objective: To explore the feasibility of the rat bone marrow stromal cells(MSCs) transplantation to treat intracerebral hemorrhage.Method: MSCs were separated from rat bone marrow and cultured with culture medium.The MSCs were purified by culture expanded in vitro and then labeled with Brdu.MSCs were transferred into rat through carotid artery and lateral ventricle.The rat neuro-logic dysfunction ameliorating was observed by behavior scores,and distribution of Brdu labeled cells in cerebra was studied.Resul... |
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| Keywords: | Intracerebral hemorrhage Mensenchymal stem cells Transplantation |
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