鼓室副神经节瘤的诊断与治疗

目的：探讨鼓室副神经节瘤的临床和病理特征。方法：复习临床病历资料，采用HE和免疫组化方法研究鼓室副神经节瘤的病理特征。结果：肿瘤实质由上皮样主细胞和短梭形支持细胞组成。主细胞中CgA、NSE和Syn呈阳性表达，支持细胞中S-100蛋白阳性表达。病理诊断为鼓室副神经节瘤，随访2年未见复发征象。结论：鼓室副神经节瘤十分罕见，临床和病理诊断困难，常需借助免疫组化协助诊断。治疗以手术切除为主。

Diagnosis and treatment of tympanic paraganglioma

Objective:To explore the clinical and pathological characteristics of tympanic araganglioma(TA).Methods:The clinical data of the patient with TA were reviewed.The tumor was studied by HE and immunohistochemistric stains.Results:The parenchyma of tumor was composed of epithelioid cells(neoplastic chief cells)and spindle sustentacular cells.In the neoplastic chief cells,CgA,NSE and Syn were posi- tive.In the sustentacular cells,S-100 protein was positive.Pathological diagnosis was primary paraganglioma.During two years' follow-up, the patient was doing well without signs of tumor recurrence.Conclusion:Tympanic paraganglioma is an extremely rare tumor.It is very difficult in the clinical and pathological diagnoses,which must depend on immunohistochemistric stains.Surgical excision is mainly performed when treat- ing.