| 介入法建立猪急性心肌梗死再灌注模型及其效果评价 |
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| 引用本文： | 胡耀鹏,马根山,祁春梅,沈成兴,陈忠,张晓黎,刘孝钧,苏亚民,李璇,金琴娣.介入法建立猪急性心肌梗死再灌注模型及其效果评价[J].现代生物医学进展,2007,7(5):667-669. |
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| 作者姓名： | 胡耀鹏 马根山 祁春梅 沈成兴 陈忠 张晓黎 刘孝钧 苏亚民 李璇 金琴娣 |
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| 作者单位： | 1. 东南大学附属中大医院心血管病研究所
2. 东南大学附属中大医院放射科,江苏,南京,210009 |
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| 基金项目： | 国家自然科学基金;国家自然科学基金 |
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| 摘 要： | 目的:用介入法行球囊堵闭猪冠状动脉左前降支(LAD)建立急性心肌梗死再灌注动物模型并评价其效果。方法:选用小型雄性家猪11只。麻醉后经股动脉或颈总动脉置入经皮腔内冠状动脉成形术(PTCA)球囊至冠状动脉LAD远端,堵闭血流60 min。术中持续静脉滴注胺碘酮。60min后负压撤除球囊及鞘管。行超声心动图、磁共振成像(MRI)评价心肌梗死模型建立情况,并行病理分析。结果:2只猪死于心肌梗死模型制备,存活的9只猪经超声心动图、MRI检测显示梗死部位均为左心室前壁、心尖区,部分模型累及室间隔,左室下壁,并有室壁瘤、室速等心肌梗死常见并发症的发生。结论:运用介入法经PTCA球囊LAD可成功建立猪急性心肌梗死模型。这种模型重复性强,可控性好,模型的梗死部位基本一致,易于术后评价。
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| 关 键 词： | 心肌梗死 动物模型 冠脉介入法 |
| 文章编号： | 24517498 |
| 修稿时间： | 01 12 2007 12:00AM |
Establishment and Evaluation of Swine model of Acute Myocardial Infarction by Interventional Technique |
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| HU Yao-peng,MA Gen-shan,QI Chun-mei,SHEN Cheng-xing,CHEN Zhong,ZHANG Xiao-li,LIU Xiao-jun,SU Ya-min,LI Xuan,JIN Qin-di.Establishment and Evaluation of Swine model of Acute Myocardial Infarction by Interventional Technique[J].Progress in Modern Biomedicine,2007,7(5):667-669. |
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| Authors: | HU Yao-peng MA Gen-shan QI Chun-mei SHEN Cheng-xing CHEN Zhong ZHANG Xiao-li LIU Xiao-jun SU Ya-min LI Xuan JIN Qin-di |
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| Institution: | 1 Department qf Cardiology,Affiliated Zhongda Hospital, Southeast University,Nanjing 210009 Jiangsu,China;2.Department of Radiology,Affiliated Zhongda Hospital,Southeast University,Nanjing 210009 Jiangsu,China |
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| Abstract: | Objective:To investigate and develop a swine model of acute myocardial infarction(AMI)by coronary occlusion with balloon angioplasty.Methods:After anesthesia,nine swine underwent 60 minutes' occlusion of coronary artery. Angioplasty balloon was positioned in the mid-distal left anterior descending(LAD).60 minutes later,the balloon was deflated and removed.Electrocardiography and blood pressure were monitored.Echocardiography,enhanced MRI and coronary angiography were also investigated to confirm AMI.Results:AMI models were successfully induced in 9 swines.AMI were confirmed by echocardiography,enhanced MRI and further pathology.Some complications of AMI occurred during the operation. Conclusions:A closed-chest swine model of AMI is feasible and relatively effective.This model proves to be reproducible, controllable,and minimally invasive. |
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| Keywords: | Myocardial infarction Swine model Coronary interventional technique |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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