Fe3O4/ 生物可降解复合材料研究

磁性氧化铁纳米粒子因具有尺寸小、低毒性和超顺磁性等特点,已经引起了生物化工、医药工业领域的广泛关注。生物可降解高分子材料是生物医用高分子研究中最活跃的领域之一,已广泛用于外科手术缝合线,植入体材料及药物释放载体等。将Fe3O4和生物可降解高分子材料进行复合,可以扩大两者的应用范围,达到理想的治疗效果,并有望开创临床治疗的新时代。本文介绍了磁性四氧化三铁粒子的化学制备方法,包括共沉淀法、溶胶-凝胶法、微乳液法,并对各种方法的优缺点进行了比较;重点阐述了磁性壳聚糖,磁性聚乳酸,磁性PEG,磁性PCL复合材料的制备,及它们在酶的固定化、磁靶向药物及基因载体等医学领域的应用,显示了Fe3O4/生物可降解复合材料在医学领域的广阔应用前景;最后对复合材料走向临床应用所面临的问题及发展前景进行了讨论。

Study on Fe3O4/biodegradable Composite Materials

Magnetic iron oxide nanoparticles due to their small size, low toxicity and superparamagnetic characteristics, have caused a bio-chemical, pharmaceutical industry research attention. Biodegradable polymer materials which have been widely used for surgical sutures, implant materials and drug delivery carrier is one of the most attractive fields in biomedical polymers. Compositing the Fe3O4 and biodegradable polymer together can expand the scope of application of both, to achieve the desired therapeutic effect, and is expected to create a new era of clinical treatment. The chemical preparation methods of Fe3O4, including co-precipitation method, sol-gel method and microemulsion method, are introduced in this paper and the advantages and disadvantages of each method are also compared; the preparation of several biodegradable composite materials mainly magnetic chitosan, magnetic PLA, magnetic PEG, magnetic PCL, and their applications in medical fields such as immobilization of the enzyme, magnetic drug targeting, and gene carrier, are also summarized, showing a broad application prospects of the Fe3O4/biodegradable composite materials in the field of medicine; finally, the problems faced in the clinical application of composite materials and development trends of Fe3O4/biodegradable composite materials are also discussed.