| HLA-DRB1基因多态性与新疆哈萨克族人群结核病易感性的研究 |
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| 引用本文： | 贺鹏,王喜,刘玉彩,吴芳,王萍,章乐,张万江.HLA-DRB1基因多态性与新疆哈萨克族人群结核病易感性的研究[J].现代生物医学进展,2010,10(1). |
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| 作者姓名： | 贺鹏 王喜 刘玉彩 吴芳 王萍 章乐 张万江 |
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| 作者单位： | 石河子大学医学院基础医学系病理生理学教研室/石河子大学《新疆地方与民族高发病》教育部重点实验室,新疆,石河子,832002 |
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| 基金项目： | 国家自然科学基金资助项目(No30760237) |
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| 摘 要： | 目的:研究HLA-DRB1基因多态性与新疆哈萨克族人群结核病(TB)的相关性。方法:采用病例-对照的研究方法,应用聚合酶链反应-序列特异性引物(PCR-SSP)技术对231例新疆哈萨克族肺结核患者和230例新疆哈萨克族健康对照者的13个HLA-DRB1等位基因进行分型,比较其等位基因频率(GF)并计算其比值比(OR)。结果:与新疆哈萨克族人群对照组相比,新疆哈萨克族人群结核病例组中HLA-DRB1*04显著增高(11.72%比6.75%,p0.05,OR=1.889),HLA-DRB1*10也增高(2.86%比1.09%),但统计学上无显著性差异(Pc0.05)。结论:HLA-DRB1*04可能是新疆哈萨克族人群结核病的易感基因。
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| 关 键 词： | 结核病 人类白细胞抗原 聚合酶链反应-序列特异性引物 |
Association of the polymorphism for the HLA-DRB1 gene and the susceptibility to tuberculosis in population of Xinjiang Kazaks |
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| HE Peng,WANG Xi,LIU Yu-cai,WU Fang,WANG Ping,ZHANG Le,ZHANG Wan-jiang.Association of the polymorphism for the HLA-DRB1 gene and the susceptibility to tuberculosis in population of Xinjiang Kazaks[J].Progress in Modern Biomedicine,2010,10(1). |
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| Authors: | HE Peng WANG Xi LIU Yu-cai WU Fang WANG Ping ZHANG Le ZHANG Wan-jiang |
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| Institution: | HE Peng,WANG Xi,LIU Yu-cai,WU Fang,WANG Ping,ZHANG Le,ZHANG Wan-jiang(Department of Pathophysiology,Medical School/Laboratory of Xinjiang Endemic , Ethnic Diseases Shihezi University,Shihezi 832002 China) |
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| Abstract: | Objective:To investigate the relationship between the polymorphism of HLA-DRB1 Gene and susceptibility to tuberculosis in Xinjiang Kazaks Population.Method:By case-control study methord,the 13 alleles of HLA-DRB1 gene sites in 231 tuberculosis cases and 230 controls Kazaks population from Xinjiang provinces were detedcted by polymerase chain reaction-sequence specific primers(PCR-SSP) technique,and gene frequency(GF) and odds ratio(OR) were calculated and compared.Results:Compared with controls,the signific... |
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| Keywords: | Tuberculosis(TB) Human leucocyte antigen(HLA) Polymerase chain reaction-Sequence-specific primers(PCR-SSP) |
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