| 小檗碱对动脉粥样硬化性损伤的保护作用 |
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| 引用本文： | 丁辉,陈鑫,曹长春范丽张日东.小檗碱对动脉粥样硬化性损伤的保护作用[J].现代生物医学进展,2011,11(2):223-226. |
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| 作者姓名： | 丁辉 陈鑫 曹长春范丽张日东 |
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| 作者单位： | 南京医科大学附属南京第一医院,江苏,南京,210006 |
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| 基金项目： | 中华医学会临床医学科研专项资金项目(09010290184) |
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| 摘 要： | 目的:探讨小檗碱对动脉粥样硬化损伤的保护作用。方法:将56只大鼠,随机分为对照组(C),高脂饮食假手术组(HD),肾动脉狭窄组(RAS),肾动脉狭窄高脂饮食组(HD+RAS)。C及RAS组给予正常饮食,HD及HD+RAS组给予高脂饮食,RAS及HD+RAS组采用固定内径银夹夹左肾动脉。饲养12周,每组处死6只进行检测,剩余除C外每日灌胃小檗碱(150mg/kg),C予以等量生理盐水灌服,持续4周,四周后处死进行相同检测,用药前后结果进行对比评价小檗碱功能。结果:与C相比,HD,RAS,HD+RAS组肌酐显著升高(P<0.05),HD及HD+RAS组胆固醇明显升高(P<0.05),超氧化物歧化酶(SOD)在HD,RAS及HD+RAS组显著降低(P<0.05),丙二醛(MDA)在HD,RAS及HD+RAS组显著增高(P<0.05),血管内皮生长因子VEGF在HC,RAS及HD+RAS组表达量升高。给予小檗碱灌胃处理后,检测指标各组间无统计学差异(P>0.05)。结论:小檗碱对动脉粥样硬化性损伤具有良好的保护作用。
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| 关 键 词： | 小檗碱 动脉粥样硬化性损伤 SOD MDA VEGF |
Protective Effect of Berberine on Atherosclerotic Injury |
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| DING Hui,CHEN Xin,CAO Chang-chun,FAN Li,ZHANG Ri-dong.Protective Effect of Berberine on Atherosclerotic Injury[J].Progress in Modern Biomedicine,2011,11(2):223-226. |
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| Authors: | DING Hui CHEN Xin CAO Chang-chun FAN Li ZHANG Ri-dong |
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| Institution: | (Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing 210006 China) |
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| Abstract: | Objective:To investigate the protect effect of Berberine on atherosclerotic injury.Methods:Fifty-six rats were randomly divided into control group(C),high-fat diet group(HD),renal artery stenosis group(RAS),high-fat diet with renal artery stenosis group(HD+RAS),fourteen in each group.C and RAS were given proper diet,HD and HD+RAS were given high fat diet.RAS and HD+RAS were clamped by sliver clip with a fixed diameter on left renal artery.12 weeks later,executed six of every group for testing,the left were ... |
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| Keywords: | Berberine Atherosclerotic injury SOD MDA VEGF |
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