| 四逆散对疲劳大鼠学习记忆及脑内GABA_B1 表达的影响 |
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| 引用本文： | 刘燕刘晓兰宋月晗范新六马佳美王霁许展嘉李峰.四逆散对疲劳大鼠学习记忆及脑内GABA_B1 表达的影响[J].现代生物医学进展,2011,11(1):5-7. |
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| 作者姓名： | 刘燕刘晓兰宋月晗范新六马佳美王霁许展嘉李峰 |
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| 作者单位： | 北京中医药大学,北京,100029 |
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| 基金项目： | 国家自然科学基金项目(30873217) |
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| 摘 要： | 目的:探讨四逆散对疲劳大鼠学习记忆及脑内GABA_B1受体的影响。方法:应用游泳训练和睡眠剥夺方法复制疲劳动物模型,运用Y-迷宫检测各组大鼠的学习记忆能力,采用免疫组化方法检测大鼠脑内GABA_B1受体阳性反应物的变化。结果:模型组与正常组相比,大鼠Y-迷宫正确反应率明显下降,错误反应率明显升高,大鼠脑内GABA_B1的阳性反应物数目明显增多;中药治疗组与模型组相比,正确反应率明显升高,错误反应次数明显下降,脑内GABA_B1受体的阳性反应物数目明显减少。结论:四逆散对疲劳大鼠学习记忆能力的下降具有改善作用。
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| 关 键 词： | 四逆散 学习记忆 GABA_B1 |
Effects of Sinisan on Learning and Memory & Expression of GABAB1
Receptor in the Brain of Fatigue Rats |
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| LIU Yan,LIU Xiao-lan,SONG Yue-han,FAN Xin-liu,MA Jia-mei,WANG Ji,XU Zhan-ji,LI Feng.Effects of Sinisan on Learning and Memory & Expression of GABAB1
Receptor in the Brain of Fatigue Rats[J].Progress in Modern Biomedicine,2011,11(1):5-7. |
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| Authors: | LIU Yan LIU Xiao-lan SONG Yue-han FAN Xin-liu MA Jia-mei WANG Ji XU Zhan-ji LI Feng |
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| Institution: | △(Beijing University of Traditional Chinese Medicine,Beijing 100029) |
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| Abstract: | Objective: To investigate the effects of Sinisan on learning and memory in fatigue model and the expression of GABA B1 receptor in rats brain.Methods: The Fatigue models were taken by the method of swimming traning and sleep deprivation.Evaluate learning and memory changes through Y maze and the changes of positive cell counts of GABA B1 receptors in rat brain by immunohis-tochemical method.Results: The correct response rate of Y-maze correctly were obviously lower in the model group than those in the norma... |
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| Keywords: | Sinisan Learning and Memory GABA B1 |
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