| 胰岛素对大鼠肠缺血再灌注损伤的影响 |
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| 引用本文： | 李东升,欧阳军,赵磊.胰岛素对大鼠肠缺血再灌注损伤的影响[J].现代生物医学进展,2011,11(2):252-255. |
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| 作者姓名： | 李东升 欧阳军 赵磊 |
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| 作者单位： | 1. 石河子大学医学院第一附属医院急诊外科,新疆,石河子,832008
2. 石河子大学医学院生理学教研室,新疆,石河子,832008 |
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| 摘 要： | 目的:观察胰岛素对大鼠肠缺血再灌注后小肠组织损伤的影响。方法:雄性SD大鼠40只随机分为4组,每组10只,手术对照组、单纯缺血组、再灌注组、胰岛素干预组。于30min缺血和120min再灌注后,进行组织病理学和生化检测。结果:(1)单纯缺血组肠粘膜损害较手术对照组明显升高(P<0.01),超氧化物歧化酶(SOD)活性无明显变化;(2)再灌注组SOD活性明显降低,与手术对照组和单纯缺血组相比较差异均有显著性(P<0.01);(3)胰岛素组SOD活性与再灌注组相比有明显改善(P<0.01)。结论:肠缺血可以引起肠粘膜损伤,再灌注则可加重这种损伤,胰岛素可以减轻再灌注损伤。
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| 关 键 词： | 小肠 缺血再灌注损伤 胰岛素 |
Effect of Insulin on Gut Injury Following Intestinal Ischemia-reperfusion |
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| LI Dong-sheng,OUYANG Jun,ZHAO Lei.Effect of Insulin on Gut Injury Following Intestinal Ischemia-reperfusion[J].Progress in Modern Biomedicine,2011,11(2):252-255. |
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| Authors: | LI Dong-sheng OUYANG Jun ZHAO Lei |
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| Institution: | LI Dong-sheng1,OUYANG Jun1,ZHAO Lei2(1 Department of Emergency Surgery,the Frist Affiliated Hospital,2 Teaching and Research Section of Physiology,Medical College of Shihezi University,Xinjiang,Shihezi 832008,China) |
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| Abstract: | Objective:To investigate the effects of insulin on gut injury following intestinal ischemia-reperfusion(I/R).Methods:Forty male SD rats were randomly divided into 4 groups,n=10 in each group:(1)control group,(2)simple ischemia group,(3)re-perfusion group,(4)insulin group.Results:(1) Mucosal injury score were significantly higher in the simple ischemia group than the control group(P<0.01),the SOD activities have no evident change;(2)The SOD activities of the re-perfusion group were significantly decreased co... |
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| Keywords: | small intestine ischemia reperfusion injury insulin |
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