盐酸美金刚联合银杏叶提取物对阿尔茨海默病患者血清BDNF、NGF、DA水平和认知功能的影响

目的:探讨盐酸美金刚联合银杏叶提取物对阿尔茨海默病患者血清脑源性神经营养因子(BDNF)、神经营养因子(NGF)浓度、多巴胺(DA)水平和认知功能的影响。方法:将我院2017年6月至2018年7月收治的92例阿尔茨海默病患者按随机数字表法分为对照组49例和研究组43例,对照组采用盐酸美金刚治疗,研究组在对照组基础上联合银杏叶提取物治疗。比较两组临床疗效,治疗前后血清BDNF、NGF、DA水平、认知功能、简易精神状态检查量表(MMSE)、日常生活能力(ADL)评分的变化和不良反应的发生情况。结果:治疗后,研究组总有效率为90.70%,显著高于对照组(69.39%,P0.05)。治疗前,两组血清BDNF、NGF、DA水平、MMSE和ADL评分比较差异无统计学意义(P0.05);治疗后,两组以上指标均较治疗前显著上升,且研究组以上指标明显高于对照组(P0.05)。两组不良反应总发生率比较差异无统计学意义(P0.05)。结论:盐酸美金刚联合银杏叶提取物可提高阿尔茨海默病的疗效,改善患者认知功能,可能与增加BDNF、NGF、DA的表达有关。

Effects of Memantine Hydrochloride Combined with Ginkgo Biloba Extract on the Serum Levels of BDNF, NGF, DA and Cognitive Function of Alzheimer's Disease Patients

ABSTRACT Objective: To investigate the effects of memantine hydrochloride combined with ginkgo biloba extract on the serum brain-derived neurotrophic factor (BDNF), neurotrophic factor (NGF) concentration, dopamine (DA) levels and cognitive function of alzheimer''s disease patients. Methods: A total of 92 patients with alzheimer''s disease admitted to our hospital from June 2017 to July 2018 were randomly divided into 49 patients in the control group and 43 patients in the research group. The control group was treated with memantine hydrochloride, and the research group was treated with ginkgo biloba extract on the basis of the control group. The clinical efficacy, changes of serum BDNF, NGF, DA levels, cognitive function, MMSE, ADL scores before and after treatment and incidence of adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of research group was 90.70%, which was significantly higher than that of the control group (69.39%, P<0.05). Before treatment, there was no significant difference in the serum levels of BDNF, NGF, DA, MMSE and ADL between the two groups (P>0.05). After treatment, the indexes in both groups were significantly higher than those before treatment, which were significantly higher in the research group than those in the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion: Memantine hydrochloride combined with ginkgo biloba extract can improve the efficacy and the cognitive function of Alzheimer''s disease patients, which may be related to the increased serum levels of BDNF, NGF and DA.